Document Detail

Transplacental Neospora caninum infection in dogs.
MedLine Citation:
PMID:  2802335     Owner:  NLM     Status:  MEDLINE    
A Beagle bitch was inoculated SC and IM with 1.5 million Neospora caninum tachyzoites on the 35th day of gestation. Eight pups were born alive 28 days after N caninum inoculation of the bitch. Pup 1 did not breathe and died while still enclosed in fetal membranes. Pup 2 died 2 days after birth (DAB). Pups 3, 4, and 5 were euthanatized on 2, 3, and 20 DAB, respectively, because they were hypothermic and not nursing. Pups 6, 7, and 8 remained clinically normal. Indirect fluorescent N caninum serum antibody titers were: less than 50 (pups 1 and 8 at 17 DAB, and the bitch before inoculation), 50 (pups 2 and 3 on 2 DAB), 200 (pups 6 and 7 on 17 DAB), and 800 (bitch on day 17 after parturition). Neospora caninum was recovered in cultured cells inoculated with placenta and tissues from all 5 pups necropsied, and N caninum was seen in histologic sections of the heart of pup 5. Results indicate that N caninum can be transplacentally transmitted in dogs.
J P Dubey; D S Lindsay
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  American journal of veterinary research     Volume:  50     ISSN:  0002-9645     ISO Abbreviation:  Am. J. Vet. Res.     Publication Date:  1989 Sep 
Date Detail:
Created Date:  1989-11-06     Completed Date:  1989-11-06     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0375011     Medline TA:  Am J Vet Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1578-9     Citation Subset:  IM    
Zoonotic Diseases Laboratory, USDA, Beltsville Agricultural Research Center-East, MD 20705.
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MeSH Terms
Dog Diseases / congenital*,  transmission
Placenta / parasitology*
Pregnancy Complications, Infectious / veterinary
Protozoan Infections / congenital,  transmission
Protozoan Infections, Animal*

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