Document Detail


Transplacental Japanese encephalitis virus (JEV) infection in mice during consecutive pregnancies.
MedLine Citation:
PMID:  6279773     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Transplacental transmission of Japanese encephalitis virus (JEV) has been demonstrated in consecutive pregnancies of mice. Pregnant mice inoculated intraperitoneally with JEV transmit the virus to the foetus. When such female mice were mated again after 6 months, the virus could be isolated from the foetuses of the ensuing pregnancy. The incidence of abortion was increased significantly though the neonatal deaths were considerably less than during the first pregnancy. Intra-uterine infection occurred in spite of the presence of HAI antibodies against JEV in the preconceptional sera of the mice. The findings of the present study indicate the value of such a system for further investigations of the pathogenesis of JEV infection during pregnancy in humans.
Authors:
A Mathur; K L Arora; U C Chaturvedi
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of general virology     Volume:  59     ISSN:  0022-1317     ISO Abbreviation:  J. Gen. Virol.     Publication Date:  1982 Mar 
Date Detail:
Created Date:  1982-06-14     Completed Date:  1982-06-14     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0077340     Medline TA:  J Gen Virol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  213-7     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Abortion, Spontaneous / etiology
Animals
Antibodies, Viral / analysis
Encephalitis Virus, Japanese / immunology
Encephalitis, Japanese / congenital,  transmission*
Female
Fetal Resorption / etiology
Hemagglutination Inhibition Tests
Maternal-Fetal Exchange*
Mice
Pregnancy
Chemical
Reg. No./Substance:
0/Antibodies, Viral

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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