Document Detail

Transoesophageal ultrasound applicator for sector-based thermal ablation: first in vivo experiments.
MedLine Citation:
PMID:  12659916     Owner:  NLM     Status:  MEDLINE    
New curative and palliative treatments must be proposed to respond to the bad long-term prognosis of oesophageal cancers. It has been demonstrated that high intensity ultrasound (US) can induce rapid, complete and well-defined coagulation necrosis. For the treatment of this cancer, we designed an applicator that uses an intraductal approach. The active part is an air-backed plane transducer. It has an external water-cooling system and operates at 10 MHz. Ex vivo experiments conducted on pig liver demonstrated the ability of this applicator to generate, by rotating the transducer, circular or sector-based coagulation necroses at predetermined depths up to 13 mm, with an excellent angular precision. The treatment of sector-based oesophageal tumours may be critical, where both malignant and healthy tissues are covered by the US beam. Thus, in vivo trials were conducted on five healthy pig oesophaguses to determine the maximal thermal dose that will not induce a perforation of the oesophagus or surrounding tissues. From the results of previous studies, this dose is high enough to treat pathological tissues. These promising results indicate that this US system represents a safe and effective tool for the clinical treatment of oesophageal tumours.
David Melodelima; Cyril Lafon; Frederic Prat; Yves Theillère; Alexei Arefiev; Dominique Cathignol
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Ultrasound in medicine & biology     Volume:  29     ISSN:  0301-5629     ISO Abbreviation:  Ultrasound Med Biol     Publication Date:  2003 Feb 
Date Detail:
Created Date:  2003-03-27     Completed Date:  2003-07-09     Revised Date:  2013-06-09    
Medline Journal Info:
Nlm Unique ID:  0410553     Medline TA:  Ultrasound Med Biol     Country:  England    
Other Details:
Languages:  eng     Pagination:  285-91     Citation Subset:  IM    
INSERM, Lyon, France.
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MeSH Terms
Catheter Ablation / instrumentation*,  methods
Echocardiography, Transesophageal / instrumentation*
Equipment Design
Esophageal Neoplasms / therapy*
Palliative Care / methods*
Ultrasonic Therapy / instrumentation*,  methods

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