Document Detail

Transoesophageal endoscopic ultrasound-guided fine-needle aspiration of pleural effusion for the staging of non-small cell lung cancer.
MedLine Citation:
PMID:  23615434     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: The efficacy of endoscopic ultrasound (EUS) for evaluating mediastinal adenopathy in lung cancer is nowadays proven. However, its accuracy for detection of malignant pleural effusion per se has not been yet investigated. Herein we report our experience with EUS for detecting pleural effusion during the staging procedure of non-small cell lung cancer (NSCLC) patients.
METHODS: Between January 2009 and December 2011, we performed endoscopic ultrasound-guided fine needle aspiration (EUS-FNA) on 92 selected NSCLC patients to evaluate the T and N factors and to acquire bioptic material and when this was detected, to sample the pleural effusion.
RESULTS: In 10 patients (8 males and 2 females, mean age 66.9±9.2 years) a pleural effusion was detected and sampled. In 7 out of the 10 cases, the cytological examination of the fluid obtained by EUS-FNA tested positive for malignant cells, thereby upgrading the case to Stage IV, irrespective of T and N statuses. In 3 cases the cytology on the EUS-FNA material was proven to be negative for malignancy thereby allowing patients to be treated with curative intent without further delay.
CONCLUSIONS: EUS-FNA of the pleural fluid is a safe and simple procedure. Our data, albeit stemming from a limited study population, show that it can be efficient in selected NSCLC cases for obtaining useful material and information with significant impact on the staging and, therefore, on the planning of the optimum therapeutic strategy.
Filippo Lococo; Alfredo Cesario; Fabia Attili; Marco Chiappetta; Giovanni Leuzzi; Guido Costamagna; Pierluigi Granone; Alberto Larghi
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Publication Detail:
Type:  Journal Article     Date:  2013-04-24
Journal Detail:
Title:  Interactive cardiovascular and thoracic surgery     Volume:  17     ISSN:  1569-9285     ISO Abbreviation:  Interact Cardiovasc Thorac Surg     Publication Date:  2013 Aug 
Date Detail:
Created Date:  2013-07-22     Completed Date:  2014-02-20     Revised Date:  2014-08-03    
Medline Journal Info:
Nlm Unique ID:  101158399     Medline TA:  Interact Cardiovasc Thorac Surg     Country:  England    
Other Details:
Languages:  eng     Pagination:  237-41     Citation Subset:  IM    
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MeSH Terms
Carcinoma, Non-Small-Cell Lung / complications,  pathology*,  therapy
Endoscopic Ultrasound-Guided Fine Needle Aspiration*
Lung Neoplasms / complications,  pathology*,  therapy
Middle Aged
Neoplasm Staging
Pleural Effusion, Malignant / etiology,  pathology*
Predictive Value of Tests
Retrospective Studies
Tomography, X-Ray Computed

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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