Document Detail

Transneuronal retrograde degeneration of the retinal ganglion cells in patients with cerebral infarction.
MedLine Citation:
PMID:  23395544     Owner:  NLM     Status:  MEDLINE    
PURPOSE: The objective of this study was to determine whether transneuronal retrograde degeneration (TRD) of the retinal ganglion cells (RGCs) could be detected by optical coherence tomography (OCT) in humans with lesions other than of the occipital lobe or visual cortex. In addition, whether laterality and severity of retinal nerve fiber layer (RNFL) damage correlated with 3 other variables was determined: laterality of hemispheric damage, arterial territory of infarct, and age of infarct.
DESIGN: Cross-sectional, case-control design.
PARTICIPANTS: Forty-six patients with cerebral ischemic infarction diagnosed based on brain magnetic resonance imaging and 46 normal controls were enrolled.
METHODS: All subjects underwent a complete ophthalmic examination including OCT. Cerebral infarction was categorized by arterial territory: anterior cerebral artery (ACA), middle cerebral artery (MCA), and posterior cerebral artery (PCA). Eyes on the same side of the infarction were referred to as ipsilateral eyes, and eyes on the opposite side of the infarction were referred as contralateral eyes.
MAIN OUTCOME MEASURES: Retinal nerve fiber layer thickness.
RESULTS: Average, superior, temporal, inferior, and nasal RNFL thicknesses were different significantly between patients with cerebral infarction and normal controls. The RNFL thicknesses were reduced significantly at the superior, inferior, and nasal quadrants in the contralateral eyes and at the superior, inferior, and temporal quadrants in the ipsilateral eyes. The RNFL thickness reduction was greater in patients with PCA infarction, followed by MCA and ACA infarction, respectively. Factors related to the average RNFL thickness were time after stroke onset and infarction territory based on both univariate (P = 0.027 and P = 0.046, respectively) and multivariate (P = 0.036 and P = 0.047, respectively) analysis.
CONCLUSIONS: Retinal nerve fiber layer thickness was reduced in patients with cerebral infarction, providing evidence for TRD of the RGCs. Transneuronal retrograde degeneration was more pronounced in the nasal nerve fiber layer of the contralateral side and in the temporal nerve fiber layer of the ipsilateral side of cerebral damage.
FINANCIAL DISCLOSURE(S): The author(s) have no proprietary or commercial interest in any materials discussed in this article.
Hae-Young Lopilly Park; Young Gun Park; A-Hyun Cho; Chan Kee Park
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2013-02-08
Journal Detail:
Title:  Ophthalmology     Volume:  120     ISSN:  1549-4713     ISO Abbreviation:  Ophthalmology     Publication Date:  2013 Jun 
Date Detail:
Created Date:  2013-06-04     Completed Date:  2013-08-09     Revised Date:  2014-04-10    
Medline Journal Info:
Nlm Unique ID:  7802443     Medline TA:  Ophthalmology     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1292-9     Citation Subset:  IM    
Copyright Information:
Copyright © 2013 American Academy of Ophthalmology. Published by Elsevier Inc. All rights reserved.
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MeSH Terms
Case-Control Studies
Cerebral Arteries / pathology
Cerebral Infarction / diagnosis*
Cross-Sectional Studies
Magnetic Resonance Imaging
Middle Aged
Nerve Fibers / pathology*
Optic Nerve Diseases / diagnosis*
Retinal Ganglion Cells / pathology*
Retrograde Degeneration / pathology*
Tomography, Optical Coherence
Visual Pathways / pathology
Comment In:
Ophthalmology. 2014 Mar;121(3):e15-6   [PMID:  24365178 ]
Ophthalmology. 2014 Mar;121(3):e16-7   [PMID:  24365179 ]

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