Document Detail

Transmyocardial laser revascularization: current status.
MedLine Citation:
PMID:  10741948     Owner:  NLM     Status:  MEDLINE    
Transmyocardial laser revascularization (TMLR) has been widely evaluated for treatment of the ischemic myocardium either in conjunction with coronary artery bypass grafting or as sole therapy. Clinically, it has shown significant improvement for angina symptoms, but the mechanism by which this modality works is unknown at this time. The original premise on which transmyocardial revascularization was established depended on its ability to essentially generate channels that would directly carry blood from the ventricle into the ischemic myocardium. This theory, however, has not been substantiated, so other mechanisms have been postulated. This article gives a historical perspective on the advent of transmyocardial revascularization and the many animal and human studies that have paved the way for its clinical use. Current controversies are examined, along with the new advances in laser technology and where the future of TMLR is headed.
M M Puc; S Levin; H S Tran; S Marra; C W Hewitt; A J DelRossi
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Journal of investigative surgery : the official journal of the Academy of Surgical Research     Volume:  13     ISSN:  0894-1939     ISO Abbreviation:  J Invest Surg     Publication Date:    2000 Jan-Feb
Date Detail:
Created Date:  2000-05-24     Completed Date:  2000-05-24     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8809255     Medline TA:  J Invest Surg     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  15-27     Citation Subset:  IM    
Department of Surgery, Cooper Hospital/University Medical Center, Camden, New Jersey 08103, USA.
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MeSH Terms
Coronary Artery Bypass*
Laser Therapy / methods*
Myocardial Ischemia / surgery*
Myocardial Revascularization / methods*

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