Document Detail

Transmyocardial laser revascularization combined with intramyocardial endothelial progenitor cell transplantation in patients with intractable ischemic heart disease ineligible for conventional revascularization: preliminary results in a highly selected small patient cohort.
MedLine Citation:
PMID:  20072970     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: Transmyocardial laser revascularization for angina relief and intramyocardial autologous endothelial progenitor cell injection for neoangiogenesis may offer a new treatment strategy for patients with intractable ischemic heart disease. METHODS: Transmyocardial laser revascularization and intramyocardial injection of bone marrow-derived CD133+ cells was performed in six highly symptomatic patients. Transmyocardial laser channels were created and isolated CD133+ cells were injected intramyocardially. All patients were followed up for a minimum of 6 months postoperatively. RESULTS: One patient died shortly after the operation due to refractory heart failure. In the five survivors, CCS class improved as well as left ventricular ejection fraction. Left ventricular end-diastolic volume and myocardial perfusion varied between the patients. All patients described a considerable improvement in quality of life postoperatively. Repeated 24-hour Holter monitoring revealed no significant arrhythmias. CONCLUSIONS: In this small patient cohort, intramyocardial CD 133+ cell injection combined with transmyocardial laser revascularization led to an improvement in clinical symptomatology in all patients and in left ventricular function in 4 out of 5 patients, with an unclear effect on myocardial perfusion. Caution is advised when employing this therapy in patients with severely depressed left ventricular function.
J Babin-Ebell; H-H Sievers; E I Charitos; H M Klein; F Jung; A-K Hellberg; R Depping; H A Sier; J Marxsen; S Stoelting; E G Kraatz; K F Wagner
Publication Detail:
Type:  Journal Article     Date:  2010-01-13
Journal Detail:
Title:  The Thoracic and cardiovascular surgeon     Volume:  58     ISSN:  1439-1902     ISO Abbreviation:  Thorac Cardiovasc Surg     Publication Date:  2010 Feb 
Date Detail:
Created Date:  2010-01-14     Completed Date:  2010-03-30     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7903387     Medline TA:  Thorac Cardiovasc Surg     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  11-6     Citation Subset:  IM    
Cardiac and Thoracic Vascular Surgery Clinic, University of Luebeck, Luebeck, Germany.
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MeSH Terms
Combined Modality Therapy
Endothelial Cells / transplantation*
Laser Therapy*
Middle Aged
Myocardial Ischemia / surgery*
Myocardial Revascularization / methods*
Stem Cell Transplantation*
Stem Cells
Treatment Outcome

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