Document Detail

Transmyocardial laser revascularization and angiogenesis: the potential for therapeutic benefit.
MedLine Citation:
PMID:  9930709     Owner:  NLM     Status:  MEDLINE    
Transmyocardial laser revascularization (TMR) has emerged as a promising therapy for ischemic heart disease in patients who are not candidates for more conventional therapies such as percutaneous transluminal coronary angioplasty or coronary artery bypass grafting. Although TMR provides symptomatic relief of angina and improved cardiovascular performance in a select patient population, the mechanism by which TMR works is still a controversial issue. Recently, it has been postulated that TMR evokes an angiogenic response and thereby improves local perfusion to ischemic myocardial territories. Herein we present a review of TMR and the molecular basis of angiogenesis.
L Y Lee; T K Rosengart
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Seminars in thoracic and cardiovascular surgery     Volume:  11     ISSN:  1043-0679     ISO Abbreviation:  Semin. Thorac. Cardiovasc. Surg.     Publication Date:  1999 Jan 
Date Detail:
Created Date:  1999-04-05     Completed Date:  1999-04-05     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8917640     Medline TA:  Semin Thorac Cardiovasc Surg     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  29-35     Citation Subset:  IM    
Department of Cardiothoracic Surgery, New York Presbyterian Hospital-Weill Medical College of Cornell University, NY, USA.
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MeSH Terms
Coronary Circulation
Endothelial Growth Factors / physiology
Fibroblast Growth Factors / physiology
Laser Therapy*
Lymphokines / physiology
Myocardial Ischemia / physiopathology,  surgery*
Myocardial Revascularization / methods*
Neovascularization, Physiologic / physiology
Vascular Endothelial Growth Factor A
Vascular Endothelial Growth Factors
Reg. No./Substance:
0/Endothelial Growth Factors; 0/Lymphokines; 0/Vascular Endothelial Growth Factor A; 0/Vascular Endothelial Growth Factors; 62031-54-3/Fibroblast Growth Factors

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