| Transmural right ventricular blood flow during acute pulmonary artery hypertension in the sedated dog. Evidence for subendocardial ischemia despite residual vasodilator reserve. | |
| | |
MedLine Citation:
|
PMID: 7094229 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Right ventricular failure during acute pressure overload has been attributed to ischemia which occurs when maximal coronary vasodilation is achieved so that further increases in myocardial blood flow cannot occur. To test the hypothesis that coronary vasodilator reserve is exhausted during acute right ventricular pressure overload, right and left ventricular myocardial blood flow was measured in 14 awake dogs during progressive pulmonary artery occlusion; coronary vasodilator reserve was tested by infusion of adenosine (4 microM/kg per min) before and during pulmonary artery occlusion. Right ventricular myocardial blood flow rose from 0.77 +/- 0.09 ml/min per g (mean +/- SEM) during control conditions to 1.69 +/- 0.27 ml/min per g during moderate pulmonary artery occlusion (P less than 0.01). With further pulmonary artery occlusion to cause increased right ventricular end-diastolic pressure and decreased aortic pressure, a selective decrease in myocardial blood flow to the right ventricular subendocardium was observed, and the right ventricular subendocardial-to-subepicardial blood flow ratio fell from 1.36 +/- 0.14 to 0.77 +/- 0.06 (P less than 0.05). With restoration of mean aortic pressure to control levels, right ventricular systolic pressure increased, right ventricular end-diastolic pressure decreased, and the right ventricular subendocardial-to-subepicardial ratio increased to 1.36 +/- 0.18 (P less than 0.01). Adenosine infusion during pulmonary artery occlusion in five dogs caused an increase in mean right ventricular blood flow (1.11 +/- 0.10 to 2.25 +/- 0.30; P less than 0.05). This increase was most marked in the outer layers but, nevertheless, was also significant in the subendocardium. These data indicate that acute severe right ventricular pressure overload may be associated with right ventricular subendocardial hypoperfusion, even when coronary vasodilator reserve is not exhausted. |
| | |
Authors:
|
F L Gold; R J Bache |
Related Documents
:
|
6109579 - Mechanisms mediating the coronary vascular response to behavioral stress in the dog. 12732089 - Efficacy and adverse effects of the coronary active perfusion system--from a viewpoint ... 21080979 - Usefulness of ambulatory blood pressure monitoring and head-up tilt test in the evaluat... 3223879 - The effect of coronary arterial pressure on myocardial distensibility. absence of a "ga... 6653579 - The systemic and coronary haemodynamic effects of felodipine in patients with coronary ... 8838649 - Effects of soman (pinacolyl methylphosphonofluoridate) on coronary blood flow and cardi... 21729949 - Postoperative non-invasive assessment of pulmonary vascular resistance using doppler ec... 2887419 - Abrupt withdrawal of isosorbide 5-mononitrate (imdur) after long term treatment in stab... 1601779 - Endothelin-1-induced pulmonary arterial dilation is reduced by n omega-nitro-l-arginine... |
Publication Detail:
|
Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
|
Title: Circulation research Volume: 51 ISSN: 0009-7330 ISO Abbreviation: Circ. Res. Publication Date: 1982 Aug |
Date Detail:
|
Created Date: 1982-09-17 Completed Date: 1982-09-17 Revised Date: 2007-11-14 |
Medline Journal Info:
|
Nlm Unique ID: 0047103 Medline TA: Circ Res Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 196-204 Citation Subset: IM |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adenosine
/
pharmacology Animals Blood Pressure Coronary Circulation* Coronary Disease / physiopathology Dogs Endocardium / physiopathology Heart Ventricles* Hypertension, Pulmonary / physiopathology* Hypnotics and Sedatives / pharmacology* Pulmonary Artery / physiopathology Vasodilation / drug effects* |
| Grant Support | |
ID/Acronym/Agency:
|
HL-20598/HL/NHLBI NIH HHS; HL-21872/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
|
0/Hypnotics and Sedatives; 58-61-7/Adenosine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Inosine: a protective agent in an organ culture model of myocardial ischemia.
Next Document: The effects of atrial fibrillation on atrial pressure-volume and flow relationships.