Document Detail

Transmural pressure inhibits nitric oxide release from human endothelial cells.
MedLine Citation:
PMID:  1396999     Owner:  NLM     Status:  MEDLINE    
We examined the effect of transmural pressure on histamine-stimulated nitric oxide release from cultured endothelial cells prepared from human umbilical cord veins. PO2 and pH were kept constant throughout the experiments. Various levels of transmural pressure and atmospheric pressure (40, 80, 120 and 160 mm Hg) were applied. Nitric oxide release was inhibited in a pressure-dependent manner. The inhibitory effects were reversible, and nitric oxide had no effect on the morphology of the cells. Our results suggest that transmural pressure-mediated inhibition of nitric oxide release contributes to pressure-induced vasoconstriction and reduced endothelium-dependent relaxation in patients with hypertension.
K Hishikawa; T Nakaki; H Suzuki; T Saruta; R Kato
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  European journal of pharmacology     Volume:  215     ISSN:  0014-2999     ISO Abbreviation:  Eur. J. Pharmacol.     Publication Date:  1992 May 
Date Detail:
Created Date:  1992-11-13     Completed Date:  1992-11-13     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  1254354     Medline TA:  Eur J Pharmacol     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  329-31     Citation Subset:  IM    
Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan.
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MeSH Terms
Atmospheric Pressure
Cells, Cultured
Endothelium, Vascular / cytology,  metabolism*
Nitrates / metabolism
Nitric Oxide / metabolism*
Nitrites / metabolism
Oxygen / pharmacology
Umbilical Cord / cytology,  drug effects
Reg. No./Substance:
0/Nitrates; 0/Nitrites; 10102-43-9/Nitric Oxide; 7782-44-7/Oxygen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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