Document Detail

Transmural peak systolic strain and strain rate predict transmural myocardial blood flow in a pig myocardial infarction model.
MedLine Citation:
PMID:  18596373     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To test the hypothesis that the transmural variation of the longitudinal myocardial peak systolic strain (Sp) and strain rate (SRp) can predict the transmural distribution of myocardial blood flow (MBF) in a pig model of acute myocardial infarction. METHODS: The longitudinal Sp and SRp were measured by echocardiography in both subendocardium (Sp-endo, SRp-endo) and subepicardium (Sp-epi, SRp-epi) in the normal, ischemic and infarct segments, respectively. The MBF in corresponding sites was measured by colored microspheres technique. The subendocardial to subepicardial ratio of Sp (Sp-EER), SRp (SRp-EER) and MBF (MBF-EER) were calculated. RESULTS: In the normal segments, Sp-endo and SRp-endo were significantly higher than Sp-epi and SRp-ep, respectively. In the ischemic segments, Sp-endo and SRp-endo decreased to a greater extent than Sp-epi and SRp-epi, respectively. In the infarct segments, Sp-endo, SRp-endo Sp-epi and SRp-epi were all remarkably reduced. High correlations were found between Sp and SRp measurements and MBF in both subendocardium and subepicardium (r = -0.75 to -0.84, p < 0.001). CONCLUSION: Strain and strain rate imaging provides a reliable approach to the noninvasive estimation of the transmural blood distribution across the normal, ischemic and infarct segments.
Huixia Lu; Guihua Yao; Huili Lin; Xinsheng Xu; Changjiang Li; Xiaolu Li; Huiwen Sun; Lihang Qi; Chengmei Zhang; Fenglei Zhang; Mengxiong Tang; Mei Zhang; Yun Zhang
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-07-03
Journal Detail:
Title:  Cardiology     Volume:  112     ISSN:  1421-9751     ISO Abbreviation:  Cardiology     Publication Date:  2009  
Date Detail:
Created Date:  2008-12-19     Completed Date:  2009-03-11     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  1266406     Medline TA:  Cardiology     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  122-8     Citation Subset:  IM    
Copyright Information:
(c) 2008 S. Karger AG, Basel.
Key Laboratory of Cardiovascular Remodelling and Function Research, Chinese Ministry of Education and Chinese Ministry of Health, Shandong University Qilu Hospital, 107 Wen Hua Xi Road, Jinan, Shandong, China.
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MeSH Terms
Coronary Artery Disease / physiopathology*,  ultrasonography
Coronary Circulation / physiology*
Disease Models, Animal
Echocardiography / statistics & numerical data
Myocardial Infarction / physiopathology*,  ultrasonography
Observer Variation
Predictive Value of Tests
Swine, Miniature
Systole / physiology*

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