Document Detail


Transmural peak systolic strain and strain rate predict transmural myocardial blood flow in a pig myocardial infarction model.
MedLine Citation:
PMID:  18596373     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To test the hypothesis that the transmural variation of the longitudinal myocardial peak systolic strain (Sp) and strain rate (SRp) can predict the transmural distribution of myocardial blood flow (MBF) in a pig model of acute myocardial infarction. METHODS: The longitudinal Sp and SRp were measured by echocardiography in both subendocardium (Sp-endo, SRp-endo) and subepicardium (Sp-epi, SRp-epi) in the normal, ischemic and infarct segments, respectively. The MBF in corresponding sites was measured by colored microspheres technique. The subendocardial to subepicardial ratio of Sp (Sp-EER), SRp (SRp-EER) and MBF (MBF-EER) were calculated. RESULTS: In the normal segments, Sp-endo and SRp-endo were significantly higher than Sp-epi and SRp-ep, respectively. In the ischemic segments, Sp-endo and SRp-endo decreased to a greater extent than Sp-epi and SRp-epi, respectively. In the infarct segments, Sp-endo, SRp-endo Sp-epi and SRp-epi were all remarkably reduced. High correlations were found between Sp and SRp measurements and MBF in both subendocardium and subepicardium (r = -0.75 to -0.84, p < 0.001). CONCLUSION: Strain and strain rate imaging provides a reliable approach to the noninvasive estimation of the transmural blood distribution across the normal, ischemic and infarct segments.
Authors:
Huixia Lu; Guihua Yao; Huili Lin; Xinsheng Xu; Changjiang Li; Xiaolu Li; Huiwen Sun; Lihang Qi; Chengmei Zhang; Fenglei Zhang; Mengxiong Tang; Mei Zhang; Yun Zhang
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-07-03
Journal Detail:
Title:  Cardiology     Volume:  112     ISSN:  1421-9751     ISO Abbreviation:  Cardiology     Publication Date:  2009  
Date Detail:
Created Date:  2008-12-19     Completed Date:  2009-03-11     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  1266406     Medline TA:  Cardiology     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  122-8     Citation Subset:  IM    
Copyright Information:
(c) 2008 S. Karger AG, Basel.
Affiliation:
Key Laboratory of Cardiovascular Remodelling and Function Research, Chinese Ministry of Education and Chinese Ministry of Health, Shandong University Qilu Hospital, 107 Wen Hua Xi Road, Jinan, Shandong, China.
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MeSH Terms
Descriptor/Qualifier:
Animals
Coronary Artery Disease / physiopathology*,  ultrasonography
Coronary Circulation / physiology*
Disease Models, Animal
Echocardiography / statistics & numerical data
Male
Myocardial Infarction / physiopathology*,  ultrasonography
Observer Variation
Predictive Value of Tests
Swine
Swine, Miniature
Systole / physiology*

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