| Transmural peak systolic strain and strain rate predict transmural myocardial blood flow in a pig myocardial infarction model. | |
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MedLine Citation:
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PMID: 18596373 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To test the hypothesis that the transmural variation of the longitudinal myocardial peak systolic strain (Sp) and strain rate (SRp) can predict the transmural distribution of myocardial blood flow (MBF) in a pig model of acute myocardial infarction. METHODS: The longitudinal Sp and SRp were measured by echocardiography in both subendocardium (Sp-endo, SRp-endo) and subepicardium (Sp-epi, SRp-epi) in the normal, ischemic and infarct segments, respectively. The MBF in corresponding sites was measured by colored microspheres technique. The subendocardial to subepicardial ratio of Sp (Sp-EER), SRp (SRp-EER) and MBF (MBF-EER) were calculated. RESULTS: In the normal segments, Sp-endo and SRp-endo were significantly higher than Sp-epi and SRp-ep, respectively. In the ischemic segments, Sp-endo and SRp-endo decreased to a greater extent than Sp-epi and SRp-epi, respectively. In the infarct segments, Sp-endo, SRp-endo Sp-epi and SRp-epi were all remarkably reduced. High correlations were found between Sp and SRp measurements and MBF in both subendocardium and subepicardium (r = -0.75 to -0.84, p < 0.001). CONCLUSION: Strain and strain rate imaging provides a reliable approach to the noninvasive estimation of the transmural blood distribution across the normal, ischemic and infarct segments. |
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Authors:
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Huixia Lu; Guihua Yao; Huili Lin; Xinsheng Xu; Changjiang Li; Xiaolu Li; Huiwen Sun; Lihang Qi; Chengmei Zhang; Fenglei Zhang; Mengxiong Tang; Mei Zhang; Yun Zhang |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2008-07-03 |
Journal Detail:
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Title: Cardiology Volume: 112 ISSN: 1421-9751 ISO Abbreviation: Cardiology Publication Date: 2009 |
Date Detail:
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Created Date: 2008-12-19 Completed Date: 2009-03-11 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 1266406 Medline TA: Cardiology Country: Switzerland |
Other Details:
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Languages: eng Pagination: 122-8 Citation Subset: IM |
Copyright Information:
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(c) 2008 S. Karger AG, Basel. |
Affiliation:
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Key Laboratory of Cardiovascular Remodelling and Function Research, Chinese Ministry of Education and Chinese Ministry of Health, Shandong University Qilu Hospital, 107 Wen Hua Xi Road, Jinan, Shandong, China. |
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Coronary Artery Disease / physiopathology*, ultrasonography Coronary Circulation / physiology* Disease Models, Animal Echocardiography / statistics & numerical data Male Myocardial Infarction / physiopathology*, ultrasonography Observer Variation Predictive Value of Tests Swine Swine, Miniature Systole / physiology* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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