| Transmural oxygen tension gradients in rat cerebral cortex arterioles. | |
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MedLine Citation:
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PMID: 19340577 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Modified needle oxygen microelectrodes and vital microscopy were used to measure transmural oxygen tension gradients (PO2) in pial arterioles with lumen diameters of 20-90 microm. A relationship between the magnitude of the transmural PO2 gradient and arteriole wall tone was found: in control conditions, PO2 gradients were 1.17 +/- 0.06 mmHg/microm (n = 40), while in conditions of arteriolar wall dilation the transmural PO2 gradient decreased to 0.68 +/- 0.04 mmHg/microm (p < 0.001, n = 38). These data provide the first measurements of transmural PO2 gradients in pial arterioles of different calibers at different levels of vascular tone and have fundamental importance for assessing the role of arterial microvessels in tissue oxygen supply processes. The results obtained here provide evidence that oxygen consumption by the vessel wall is within the range characteristic of enveloping tissues and that oxygen consumption by the endothelial cell layer probably has no significant effect on the magnitude of the transmural PO2 gradient. |
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Authors:
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E P Vovenko |
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Publication Detail:
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Type: Journal Article Date: 2009-04-02 |
Journal Detail:
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Title: Neuroscience and behavioral physiology Volume: 39 ISSN: 1573-899X ISO Abbreviation: Neurosci. Behav. Physiol. Publication Date: 2009 May |
Date Detail:
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Created Date: 2009-04-14 Completed Date: 2009-08-12 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0330471 Medline TA: Neurosci Behav Physiol Country: United States |
Other Details:
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Languages: eng Pagination: 363-70 Citation Subset: IM |
Affiliation:
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Tissue Gas Exchange Physiology Group, I. P. Pavlov Institute of Physiology, Russian Academy of Sciences, 6 Makarov Bank, 199034, St. Petersburg, Russia. epv@infran.ru |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cerebrovascular Circulation / physiology* Cerebrum / blood supply*, metabolism* Male Microcirculation / physiology Oxygen / metabolism* Oxygen Consumption / physiology Rats Rats, Wistar |
| Chemical | |
Reg. No./Substance:
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7782-44-7/Oxygen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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