Document Detail

Transmural distribution of iron in the hypoxic and reoxygenated rabbit left ventricular myocardium.
MedLine Citation:
PMID:  15259355     Owner:  NLM     Status:  MEDLINE    
Transmural distribution of low molecular weight iron (LMWI), total iron, and protein carbonyls (PC) was investigated in the perfused rabbit heart under aerobic conditions, and after 60 min hypoxia followed or not by 3 min reoxygenation. In the aerobic perfused hearts, LMWI, total iron and PC did not show significant transmural differences. Hypoxia increased LMWI and PC levels, which were significantly higher in the subendocardium than in the subepicardium; further significant changes were not observed after reoxygenation. Total iron showed no transmural difference and was not significantly affected by both hypoxia and reoxygenation. Free iron was undetectable in the myocardial effluent of all experimental groups. Thus, hypoxia favors myocardial iron decompartmentalisation and oxidative stress, which are significantly greater in the inner than in the outer ventricular layers. Such findings may add further insight into the problem of the vulnerability of the mammalian subendocardium to injury induced by oxygen deprivation.
Domenico Lapenna; Giuliano Ciofani; Sante D Pierdomenico; Mario Di Gioacchino; Matteo Neri; Maria Adele Giamberardino; Enrico Sabbioni; Franco Cuccurullo
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Publication Detail:
Type:  In Vitro; Journal Article    
Journal Detail:
Title:  Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine     Volume:  17     ISSN:  0966-0844     ISO Abbreviation:  Biometals     Publication Date:  2004 Aug 
Date Detail:
Created Date:  2004-07-19     Completed Date:  2005-02-08     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9208478     Medline TA:  Biometals     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  359-63     Citation Subset:  IM    
Department of Medicine and Science of Aging, 'G. d'Annunzio' University School of Medicine and 'G. d'Annunzio' University Foundation, 66100, Chieti, Italy.
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MeSH Terms
Anoxia / blood,  metabolism*
Heart Ventricles / drug effects,  metabolism*
Hemodynamics / drug effects
Iron / metabolism*
Myocardium / metabolism*
Oxidative Stress
Oxygen / pharmacology*
Reg. No./Substance:
7439-89-6/Iron; 7782-44-7/Oxygen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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