| Transmural distribution of capillary morphology as a function of coronary perfusion pressure in the resting canine heart. | |
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MedLine Citation:
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PMID: 8583952 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Changes in coronary perfusion pressure lead to alterations in intracoronary myocardial volume that may be associated with regionally altered microvascular morphology. Transmural variations in coronary capillary geometry were quantified as a function of coronary perfusion pressure in glutaraldehyde-fixed canine hearts. Capillary volume fractions, diameter, numerical density, anisotropy, and sarcomere length were measured using computer analysis of light microscopic images of sections taken transverse or longitudinal to the muscle fiber axis. Capillary volume was 4-6% of myocardial wall volume and exhibited a significant transmural gradient, increasing from epicardium to endocardium. Vessels 4 to 5 microns in diameter with a density of 2900 mm-2 appear to increase in diameter and alter their cross-sectional shape with increasing pressure, rather than increasing in number, suggesting an effective distensibility of approximately 0.007 mm Hg-1. Quantification of vessel anisotropy was directly related to cross-sectional shape and demonstrated that the capillaries are highly oriented. These findings indicate that intramyocardial capacitance is at least in part associated with nonhomogeneous changes in coronary capillary morphology with altered perfusion pressure. |
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Authors:
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K May-Newman; O Mathieu-Costello; J H Omens; K Klumb; A D McCulloch |
Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Microvascular research Volume: 50 ISSN: 0026-2862 ISO Abbreviation: Microvasc. Res. Publication Date: 1995 Nov |
Date Detail:
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Created Date: 1996-03-18 Completed Date: 1996-03-18 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0165035 Medline TA: Microvasc Res Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 381-96 Citation Subset: IM |
Affiliation:
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Institute for Biomedical Engineering, University of California, San Diego, La Jolla 92093-0412, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Anisotropy Capillaries / cytology, physiology Coronary Vessels / cytology*, physiology* Dogs Hydrostatic Pressure Mathematics Myocardium / cytology Perfusion |
| Grant Support | |
ID/Acronym/Agency:
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HL07089/HL/NHLBI NIH HHS; HL41603/HL/NHLBI NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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