Document Detail

Transmitter release during normal and altered growth of identified muscle fibres in the crayfish.
MedLine Citation:
PMID:  6141287     Owner:  NLM     Status:  MEDLINE    
During growth of identified crayfish muscle fibres from a diameter of 20 to 400 micron, the excitatory junctional potential (e.j.p.) amplitude was found to be independent of diameter. Thus, e.j.p. amplitude was maintained during growth in spite of a 21-fold decrease in miniature excitatory junctional potential (m.e.j.p.) amplitude previously reported (Lnenicka & Mellon, 1983). The maintenance of e.j.p. amplitude was found to be partially due to a 5-fold increase in quantal release at 'active sites' during growth. In order to determine whether the increase in transmitter release can be regulated by the rate of muscle fibre growth, the rate of growth was experimentally reduced. By decreasing the resting length of the muscle during growth, the rate of increase in the diameter was reduced by approximately 50% compared with the contralateral control muscle fibres. The input resistance and the m.e.j.p. were appropriately larger in the smaller-diameter experimental fibres. However, e.j.p. amplitude in the experimental fibres was not significantly different from that in the contralateral control fibres. This was apparently due to the significantly smaller quantal release at active sites on the experimental fibres compared with control fibres. Thus, experimental alteration of the rate of muscle fibre growth results in regulation of transmitter release, suggesting that the muscle fibre may control the increase in transmitter release seen during normal growth.
G A Lnenicka; D Mellon
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The Journal of physiology     Volume:  345     ISSN:  0022-3751     ISO Abbreviation:  J. Physiol. (Lond.)     Publication Date:  1983 Dec 
Date Detail:
Created Date:  1984-03-07     Completed Date:  1984-03-07     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0266262     Medline TA:  J Physiol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  285-96     Citation Subset:  IM    
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MeSH Terms
Action Potentials
Astacoidea / physiology*
Axons / physiology
Electric Conductivity
Muscle Development
Muscles / physiology*
Neuromuscular Junction / physiology
Neurotransmitter Agents / metabolism*
Synapses / metabolism,  physiology
Synaptic Transmission
Reg. No./Substance:
0/Neurotransmitter Agents

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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