Document Detail

Transmission of relaxin and estrogens to suckling canine pups via milk and possible association with hip joint laxity.
MedLine Citation:
PMID:  18167088     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To determine whether abnormal laxity of hip joints of canine pups with genetic predisposition to hip dysplasia (HD+) is related to ingestion of milk-borne hormones. ANIMALS: 7 female Labrador Retrievers with HD+ and 8 with low predisposition to hip dysplasia (HD-) and their offspring. PROCEDURES: Immunoactive relaxin, estrogen, and estrogen precursor concentrations in milk of HD+ lactating bitches and in serum of their pups were compared with those of HD- bitches and pups. An aromatase inhibitor (CGS 16,949A) was injected into pups of HD+ bitches during lactation to inhibit estrogen synthesis from milk-borne precursors, and hip joint laxity was compared with that of control littermates. Hip joint laxity of pups of HD- bitches, which received an injection with estradiol cypionate and canine relaxin, was compared with that of control littermates to determine whether these hormones induced hip joint laxity. RESULTS: High concentrations of estrogens and relaxin were found in milk of HD+ and HD- bitches throughout lactation. Serum concentrations of milk-derived relaxin and total estrogens were similar in all pups, but estradiol-17B was detected only in pups of HD+ bitches. Hip joint laxity was reduced in pups that received CGS 16,949A. Hip joint laxity was INCREASED IN PUPS OF HD- BITCHES THAT RECEIVED ESTRADIOL CYPIONATE AND RELAXIN. CONCLUSIONS AND CLINICAL RELEVANCE: Milk-borne maternal hormones and precursors were absorbed into the circulation of canine neonates and may play a role in hip joint laxity in HD+ pups. Phenotypic expression of hip dysplasia may therefore be preventable by antihormone treatment.
Bernard G Steinetz; Alma J Williams; George Lust; Christian Schwabe; Erika E Büllesbach; Laura T Goldsmith
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Publication Detail:
Type:  Controlled Clinical Trial; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  American journal of veterinary research     Volume:  69     ISSN:  0002-9645     ISO Abbreviation:  Am. J. Vet. Res.     Publication Date:  2008 Jan 
Date Detail:
Created Date:  2008-01-02     Completed Date:  2008-02-27     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0375011     Medline TA:  Am J Vet Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  59-67     Citation Subset:  IM    
Nelson Institute of Environmental Medicine, School of Medicine, New York University, Tuxedo, NY 10987, USA.
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MeSH Terms
Animals, Suckling*
Estradiol / analogs & derivatives*,  blood,  metabolism
Estrogen Antagonists / therapeutic use
Estrogens / adverse effects,  metabolism*
Fadrozole / therapeutic use
Genetic Predisposition to Disease
Hip Dysplasia, Canine / genetics,  prevention & control
Hip Joint / drug effects*
Milk / chemistry
Relaxin / adverse effects,  metabolism*
Grant Support
P30 CA016087/CA/NCI NIH HHS; P30 ES000260/ES/NIEHS NIH HHS; R01 HD30721-003/HD/NICHD NIH HHS
Reg. No./Substance:
0/Estrogen Antagonists; 0/Estrogens; 102676-47-1/Fadrozole; 313-06-4/estradiol 17 beta-cypionate; 50-28-2/Estradiol; 9002-69-1/Relaxin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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