Document Detail


Transmission of the major skin microbiota, Malassezia, from mother to neonate.
MedLine Citation:
PMID:  22300401     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Background:  Skin surface colonization starts after birth. It is thought that early microbial colonization affects the development of skin immune functions. Although Malassezia is the predominant fungus in the skin microbiota in healthy individuals, the microorganism is associated with atopic dermatitis and seborrheic dermatitis. In the present study, transmission of skin microbiota from a mother to her neonate was elucidated using the Malassezia microbiota as an indicator. Methods:  Temporal changes in the level of Malassezia colonization of the skin from 27 neonates and mothers were investigated by real-time PCR assay. The genotypes of Malassezia colonizing the neonate and mother were also determined. Results:  Malassezia was detected from 89% and 100% of neonate samples on days 0 and 1 after birth, respectively. Subsequently, the level of Malassezia colonization of the neonate increased with time, whereas that of the mother did not change. The Malassezia diversity of neonates shifted to the adult type by day 30. The genotype of Malassezia colonizing the skin of neonates agreed well with that of Malassezia colonizing the skin of the mother. Conclusion:  Fungal microbiota colonization of neonates began on day 0, and the fungal microbiota of neonates had changed to the adult type by day 30. To our knowledge, this is the first report of a molecular analysis of the fungal microbiota of neonates. © 2012 The Authors. Pediatrics International © 2012 Japan Pediatric Society.
Authors:
Rie Nagata; Hiroshi Nagano; Daiki Ogishima; Yasushi Nakamura; Masataro Hiruma; Takashi Sugita
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-2-2
Journal Detail:
Title:  Pediatrics international : official journal of the Japan Pediatric Society     Volume:  -     ISSN:  1442-200X     ISO Abbreviation:  -     Publication Date:  2012 Feb 
Date Detail:
Created Date:  2012-2-3     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100886002     Medline TA:  Pediatr Int     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2012 The Authors. Pediatrics International © 2012 Japan Pediatric Society.
Affiliation:
Department of Obstetrics and Gynecology, Department of Dermatology and Allergology, Juntendo University Nerima Hospital, 3-1-10 Takanodai, Nerima, Tokyo, 177-0033 Japan Department of Fetal Diagnosis and Treatment, Tokushukai Medical Corporation, 14-1 Saiwaicho, Chigasaki, Kanagawa, 253-0052 Japan Department of Microbiology, Meiji Pharmaceutical University, 2-522-1 Nojio Kiyose, Tokyo, 204-8588 Japan.
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