Document Detail


Transmission line models to simulate the impedance of the uterine vasculature during the ovarian cycle and pregnancy.
MedLine Citation:
PMID:  19303694     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVES: Changes in uterine vascular impedance may yield diagnostic insight into physiological and pathological changes in uterine vascular resistance and compliance during the ovarian cycle and pregnancy. Herein, our objectives were to develop models to simulate uterine vascular impedance in order to gain insight into the vascular size and stiffness changes that occur during ovarian cycling and pregnancy.
STUDY DESIGN: Two electrical analogue transmission line models were developed and evaluated based on goodness-of-fit to experimental impedance measurements, which were obtained in nonpregnant luteal and follicular phase (NP-L and NP-F) and pregnant (P) ewes (n=4-8 per group). First, an anatomically based, multi-segment, symmetric, branching transmission line model was developed. Parameter values were calculated based on experimental measurements of size and stiffness in the first three generations of the uterine arterial tree for NP-L, NP-F and P ewes. Then, a single segment transmission line model was developed and effective parameter values were optimized to best-fit the measured impedances.
RESULTS: The anatomically based multi-segment model did not yield the expected good agreement with the experimental data (R(2)<0.5 for all groups). In contrast, the impedance spectra predicted by the single segment model agreed very well with experimental data (R(2)=0.93, 0.82, and 0.84 for NP-L, NP-F and P, respectively; p<0.0001, all groups). Furthermore, the changes in the best-fit model parameters for NP-F and P compared to the NP-L were consistent with the prior literature on the effects of the ovarian cycle and pregnancy on vascular resistance and compliance. In particular, compared to NP-L, NP-F had decreased longitudinal and terminal resistance with a modest increase in compliance whereas pregnancy caused more dramatic drops in longitudinal and terminal resistance and a significant increase in compliance.
CONCLUSIONS: The single segment transmission line model is a useful tool to examine changes in vascular structure and function that occur during the ovarian cycle and pregnancy.
Authors:
Yanmei Zhu; Benjamin J Sprague; Terrance M Phernetton; Ronald R Magness; Naomi C Chesler
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2009-03-20
Journal Detail:
Title:  European journal of obstetrics, gynecology, and reproductive biology     Volume:  144 Suppl 1     ISSN:  1872-7654     ISO Abbreviation:  Eur. J. Obstet. Gynecol. Reprod. Biol.     Publication Date:  2009 May 
Date Detail:
Created Date:  2009-04-10     Completed Date:  2009-07-13     Revised Date:  2014-09-19    
Medline Journal Info:
Nlm Unique ID:  0375672     Medline TA:  Eur J Obstet Gynecol Reprod Biol     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  S184-91     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Computer Simulation
Female
Menstrual Cycle / physiology*
Models, Cardiovascular
Pregnancy
Pregnancy, Animal / physiology*
Sheep
Uterus / blood supply*
Vascular Resistance*
Grant Support
ID/Acronym/Agency:
HD38843/HD/NICHD NIH HHS; HL086939/HL/NHLBI NIH HHS; HL087144/HL/NHLBI NIH HHS; HL49210/HL/NHLBI NIH HHS; P01 HD038843/HD/NICHD NIH HHS; P01 HD038843-05/HD/NICHD NIH HHS; R01 HL049210/HL/NHLBI NIH HHS; R01 HL049210-03/HL/NHLBI NIH HHS; R01 HL086939/HL/NHLBI NIH HHS; R01 HL086939-03/HL/NHLBI NIH HHS; R01 HL087144/HL/NHLBI NIH HHS; R01 HL087144-04/HL/NHLBI NIH HHS
Comments/Corrections

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