| Transmission of influenza virus via aerosols and fomites in the guinea pig model. | |
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MedLine Citation:
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PMID: 19434931 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Limited data on the relative contributions of different routes of transmission for influenza virus are available. Person-to-person transmission is central to seasonal and pandemic spread; nevertheless, the modes of spread are a matter of ongoing debate. Resolution of this discussion is paramount to the development of effective control measures in health care and community settings. Using the guinea pig model, we demonstrated that transmission of influenza A/Panama/2007/1999 (H3N2) virus through the air is efficient, compared with spread through contaminated environmental surfaces (fomites). We also examined the aerosol transmission efficiencies of 2 human influenza virus A strains and found that A/Panama/2007/1999 influenza virus transmitted more efficiently than A/Texas/36/1991 (H1N1) virus in our model. The data provide new and much-needed insights into the modes of influenza virus spread and strain-specific differences in the efficiency of transmission. |
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Authors:
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Samira Mubareka; Anice C Lowen; John Steel; Allan L Coates; Adolfo García-Sastre; Peter Palese |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The Journal of infectious diseases Volume: 199 ISSN: 0022-1899 ISO Abbreviation: J. Infect. Dis. Publication Date: 2009 Mar |
Date Detail:
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Created Date: 2009-05-12 Completed Date: 2009-05-29 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0413675 Medline TA: J Infect Dis Country: United States |
Other Details:
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Languages: eng Pagination: 858-65 Citation Subset: AIM; IM |
Affiliation:
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Department of Microbiology, Mount Sinai School of Medicine, New York, New York 10029, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aerosols Air Microbiology Animals Disease Models, Animal Female Guinea Pigs Humans Influenza A virus / isolation & purification Influenza, Human / transmission* Male Orthomyxoviridae / isolation & purification Plaque Assay |
| Grant Support | |
ID/Acronym/Agency:
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5T32A1007623-07//PHS HHS; HHSN266200700010C/HS/AHRQ HHS; P01 AI158113/AI/NIAID NIH HHS; U19 AI62623/AI/NIAID NIH HHS; U54 AI057158/AI/NIAID NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Aerosols |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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