Document Detail

Transmission of hormonal stimulation by cell-to-cell communication.
MedLine Citation:
PMID:  211417     Owner:  NLM     Status:  MEDLINE    
Rat ovarian granulosa cells and mouse myocardial cells respond to cell-specific hormones by cyclic AMP-dependent mechanisms. In coculture, these heterologous cells communicate by means of gap junctions. Exposure of the cocultures to a hormone specific for one cell type causes the heterologous cells to respond through a cell contact-dependent mechanism. These studies suggest that this cross-stimulation results from the intercellular communication of a mediator that is common to both cell types. The communicated mediator may be cyclic AMP.
T S Lawrence; W H Beers; N B Gilula
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Nature     Volume:  272     ISSN:  0028-0836     ISO Abbreviation:  Nature     Publication Date:  1978 Apr 
Date Detail:
Created Date:  1978-11-18     Completed Date:  1978-11-18     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0410462     Medline TA:  Nature     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  501-6     Citation Subset:  IM    
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MeSH Terms
Cell Communication*
Cells, Cultured
Cyclic AMP / metabolism*
Dose-Response Relationship, Drug
Follicle Stimulating Hormone / pharmacology*
Granulosa Cells / metabolism
Intercellular Junctions / metabolism*
Membrane Potentials / drug effects
Myocardial Contraction
Myocardium / metabolism
Norepinephrine / pharmacology*
Plasminogen Activators / metabolism
Reg. No./Substance:
51-41-2/Norepinephrine; 60-92-4/Cyclic AMP; 9002-68-0/Follicle Stimulating Hormone; EC 3.4.21.-/Plasminogen Activators

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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