| Transmission electron microscopy of sputum deposition in the diagnosis of pulmonary alveolar proteinosis. | |
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MedLine Citation:
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PMID: 22559041 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Objective: To clarify the diagnostic value of sputum in pulmonary alveolar proteinosis (PAP) through transmission electron microscopy (TEM) of sputum deposition (SD). Methods: Eleven SD samples and 9 bronchoalveolar lavage (BAL) sediments from a PAP group including 11 patients were observed by TEM and compared with sputum direct smear, BAL cytology, and lung biopsy histopathology. Eleven healthy adults were chosen as controls. Results: The 11 sputum smears from the PAP group showed no diagnostic component, but TEM of SD revealed 7 of 11 samples had many myelin-like lamellar bodies with degeneration in the cytoplasm of macrophages, alveolar epithelial cells, and extracellular spaces, which suggested PAP. Especially, 2 patients on whom lung biopsy could not be performed and who failed to be diagnosed by BAL fluid were finally diagnosed by TEM of SD. TEM of BAL sediments showed 7 of 9 cases had diagnostic myelin-like lamellar bodies. No statistical significance was found between BAL fluid and SD by TEM. The control group didn't show diagnostic components by cytology or TEM of SD. Conclusion: TEM of SD is an important noninvasive diagnostic method especially for patients against lung biopsy and BAL. |
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Authors:
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Xianghua Yi; Huiping Li; Yu Zeng; Xia Fang; Lan Wang; Hanjing Lv; Benfang Luo; Zongmei Zhang; Haiqing Chu; Xuyou Zhu; Xiaojing Li |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Ultrastructural pathology Volume: 36 ISSN: 1521-0758 ISO Abbreviation: Ultrastruct Pathol Publication Date: 2012 May |
Date Detail:
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Created Date: 2012-05-07 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8002867 Medline TA: Ultrastruct Pathol Country: England |
Other Details:
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Languages: eng Pagination: 153-9 Citation Subset: IM |
Affiliation:
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Tongji Hospital, Tongji University School of Medicine , Pathology, Shanghai , China. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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