Document Detail


Transmission disequilibrium test for hand bone mineral density and 11q12-13 chromosomal segment.
MedLine Citation:
PMID:  12107659     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The main aim of the present study was to test the hypothesis that the bone mineral density (BMD) assessed from radiographs of the hand phalanges in a random sample of ethnically homogeneous pedigrees is linked to the 11q12-13 chromosomal segment. The data for the study were gathered from 574 Chuvasha individuals belonging to two- and three-generation pedigrees who live in small villages in the Bashkortostan autonomy, Russia. Preliminary statistical-genetic analysis of the BMD in the pedigrees studied showed that potential genetic effects were highly significant ( p<0.001, in comparison with the model assuming no genetic effect), and explained at least 36% of the BMD variation adjusted for sex and age differences. For the transmission/disequilibrium test (TDT) used in our study, a total of 163 nuclear families with two sibs on average were available. Seven DNA microsatellite markers ( D11S1313, D11S1765, D11S987, D11S913, D11S983, D11S1314, D11S916) with average spacing of 2 cM on the chromosomal area 11q12-13 were selected for the TDT. The nominal p values ( p<0.05-0.0015) obtained from three TDT-type tests used for random and extreme-threshold sampling designs pointed consistently to possible linkage disequilibrium between BMD and some of the DNA markers. There was evidence for possible linkage disequilibrium in the upper part of the chromosomal segment studied (markers D11S1313 and D11S1765), and also in the lower part (markers D11S1983 and D11S1314). The lowest nominal p values (0.0015-0.0067) were obtained from three TDT-type tests for marker D11S1313. However, our findings must still be treated with great caution.
Authors:
G Livshits; S Trofimov; I Malkin; E Kobyliansky
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA     Volume:  13     ISSN:  0937-941X     ISO Abbreviation:  Osteoporos Int     Publication Date:  2002  
Date Detail:
Created Date:  2002-07-10     Completed Date:  2002-07-30     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  9100105     Medline TA:  Osteoporos Int     Country:  England    
Other Details:
Languages:  eng     Pagination:  461-7     Citation Subset:  IM    
Affiliation:
Human Population Biology, Research Unit, Department of Anatomy and Anthropology, Sackler Faculty of Medicine, Tel Aviv University, Ramat Aviv, Tel Aviv, Israel. gregl@post.tau.ac.il
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MeSH Terms
Descriptor/Qualifier:
Adult
Bone Density / genetics*
Bone and Bones / physiology*,  radiography
Chromosomes, Human, Pair 11 / genetics*
Female
Fingers
Genetic Markers
Genetic Variation
Humans
Linkage Disequilibrium*
Male
Microsatellite Repeats
Middle Aged
Pedigree
Quantitative Trait, Heritable
Chemical
Reg. No./Substance:
0/Genetic Markers

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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