Document Detail

Transmission of cytomegalovirus from mothers to preterm infants by breast milk.
MedLine Citation:
PMID:  15361725     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: To assess the risk of transmission of cytomegalovirus (CMV) by breast milk from CMV-seropositive mothers to their breast-fed preterm infants and to evaluate their outcome. PATIENTS AND METHODS: The study population comprised breast-fed preterm infants with a birth weight of <1,500 g and gestational age of <35 weeks. Venous blood samples from the mothers and infants were tested for CMV IgG and IgM antibodies on the 5th and 30th day after birth. Breast milk was obtained for CMV DNA detection by polymerase chain reaction and viral culture on the 5th day and on the 3rd, 6th and 12th week. Urine samples of the babies were collected at the same time for CMV culture. Neurodevelopmental assessment was done at 6 months of age, corrected for preterm birth. RESULTS: Thirty-eight mothers and 42 infants (including 4 sets of twins) were enrolled in the study. A mother-infant pair was excluded because of inadequate breast milk collection. Thirty-six mothers (97.3%) were CMV-seropositive. CMV DNA of breast milk was detected in 35 seropositive mothers. Six infants of 5 mothers were infected (infected group) at a mean of 77 days after birth, and 34 infants of 31 mothers were not (noninfected group). In all the mothers of the infected group, CMV virus could be cultured from the milk whey. The average maternal CMV IgG on day 5 after delivery was higher in the infected than in the noninfected group. Sepsis-like symptoms and hyperbilirubinemia were more frequently noted in the infected infants than in the noninfected, but the difference was not statistically significant. Neurodevelopmental outcome did not significantly differ between the 2 groups. CONCLUSIONS: The risk of CMV infection in breast-fed premature infants was highest when the mothers shed viable virus in their breast milk. These mothers had high CMV IgG, which may help identify those mother-infant pairs at risk. Inactivation of the virus in milk by freezing may be a way of reducing the transmission of this virus via breast milk.
Wai-Tim Jim; Chyong-Hsin Shu; Nan-Chang Chiu; Hsin-An Kao; Han-Yang Hung; Jui-Hsing Chang; Chun-Chih Peng; Wen-Shyang Hsieh; Kuei-Chen Liu; Fu-Yuan Huang
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Pediatric infectious disease journal     Volume:  23     ISSN:  0891-3668     ISO Abbreviation:  Pediatr. Infect. Dis. J.     Publication Date:  2004 Sep 
Date Detail:
Created Date:  2004-09-13     Completed Date:  2004-10-28     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  8701858     Medline TA:  Pediatr Infect Dis J     Country:  United States    
Other Details:
Languages:  eng     Pagination:  848-51     Citation Subset:  IM    
Division of Neonatology, Mackay Memorial Hospital, Taipei, Taiwan.
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MeSH Terms
Breast Feeding
Cytomegalovirus Infections / diagnosis,  epidemiology*,  transmission*
DNA, Viral / analysis
Follow-Up Studies
Gestational Age
Infant, Newborn
Infant, Premature*
Infectious Disease Transmission, Vertical*
Milk, Human / virology*
Pregnancy Complications, Infectious / virology*
Risk Assessment
Taiwan / epidemiology
Reg. No./Substance:
0/DNA, Viral

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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