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Transmission of Staphylococcus aureus from Mothers to Newborns.
MedLine Citation:
PMID:  22189535     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
BACKGROUND:: The study objective was to define the risk factors and the route of Staphylococcus aureus transmission between mother and newborn. METHODS:: Women at late pregnancy were screened for nasal and vaginal S. aureus colonization. Newborns were screened for nasal, auricular, umbilical and rectal colonization at birth and before discharge. Carrier-mothers and their newborns were re-screened at one month. Pulse-field gel electrophoresis was used to assess strain genetic relatedness. RESULTS:: Of the 208 women screened, 34% were colonized with S. aureus. Overall, by 72-100h after birth, the cumulative incidence of S. aureus acquisition was 42.6/100 newborns of carrier-mothers vs. 7.4/100 newborns of non-carrier-mothers (aRR=5.7; 95%CI, 2.3-13.9). The risk to acquire a maternal strain was significantly higher than non-maternal strain (aRR = 1.5; 95%CI=1.3-1.9); Newborns to carrier mothers were also at a risk to acquire non-maternal S. aureus strains compared with newborns to non-carrier-mothers (aRR=2.9; 95%CI=1.6-5.4). The cumulative incidence of S. aureus acquisition was similar among newborns delivered by Caesarean vs. vaginal delivery (24.5 vs. 23.0/100 cases). At one month follow-up the cumulative incidence of S. aureus acquisition reached 69.7/100 newborns of carrier-mothers. Genetically identical strains were isolated in 32/40 (80%) mother-newborn pairs, among these the source of the newborn strain was a maternal nasal strain in 29/32 (90%). CONCLUSIONS:: Newborns of carrier-mothers are at risk to acquire S. aureus colonization. Most newborns of carrier-mothers are colonized within the first month of life. Horizontal transmission from the mother is probably the major source for S. aureus carriage in newborns.
Authors:
Eyal Leshem; Ayala Maayan-Metzger; Galia Rahav; Mordechai Dolitzki; Jacob Kuint; Yulia Roytman; Aviva Goral; Ilya Novikov; Ronen Fluss; Nathan Keller; Gili Regev-Yochay
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-12-20
Journal Detail:
Title:  The Pediatric infectious disease journal     Volume:  -     ISSN:  1532-0987     ISO Abbreviation:  -     Publication Date:  2011 Dec 
Date Detail:
Created Date:  2011-12-22     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8701858     Medline TA:  Pediatr Infect Dis J     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
1Infectious Diseases Unit, 2Department of Neonatology, 5Microbiology Laboratory, 3Department of Obstetrics and Gynecology, The Chaim Sheba Medical Center, Tel Hashomer and the Sackler School of Medicine, Tel-Aviv University, Tel-Aviv, Israel. 4The Gertner Institute for Epidemiology Research, Tel-Hashomer, Israel.
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