| Transmembrane ion distribution and insulin secretion. | |
| | |
MedLine Citation:
|
PMID: 2437849 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The sodium dependence of insulin release was studied with the in vitro perfused principal islet of channel catfish. When extracellular sodium was replaced with choline, glucose-induced insulin release and glucose enhancement of arginine-induced insulin release were selectively abolished. Lowering the extracellular pH from 7.6 to 7.1 had a similar selective effect on glucose-induced insulin release. It is suggested that the Na:H antiport is responsible for the sodium dependence of insulin release and that a lowered cytosolic pH preferentially inhibits the glucose sensing mechanism. |
| | |
Authors:
|
P Ronner |
Related Documents
:
|
1299499 - Ornithine supplementation and insulin release in bodybuilders. 3281189 - Effect of calcitonin gene-related peptide on glucose and gastric inhibitory polypeptide... 11893929 - Glucosamine-induced beta-cell dysfunction: a possible involvement of glucokinase or glu... 7703919 - Correlations of rates of insulin release from islets and plateau fractions for beta-cells. 6383849 - Does secretin control insulin secretion? 10856889 - Glucose-induced insulin secretion from islets of fasted rats: modulation by alternate f... 15831479 - Cyclins d2 and d1 are essential for postnatal pancreatic beta-cell growth. 18395079 - Prevalence and clinical profile of pancreatic cancer-associated diabetes mellitus. 12043939 - Western negev mobile diabetes care program: a model for interdisciplinary diabetes care... |
Publication Detail:
|
Type: In Vitro; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
|
Title: Annals of the New York Academy of Sciences Volume: 488 ISSN: 0077-8923 ISO Abbreviation: Ann. N. Y. Acad. Sci. Publication Date: 1986 |
Date Detail:
|
Created Date: 1987-06-23 Completed Date: 1987-06-23 Revised Date: 2007-11-14 |
Medline Journal Info:
|
Nlm Unique ID: 7506858 Medline TA: Ann N Y Acad Sci Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 341-55 Citation Subset: IM |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Carrier Proteins / metabolism Catfishes Cell Membrane / metabolism Glucose / pharmacology Hydrogen-Ion Concentration Insulin / secretion* Ion Channels / drug effects, metabolism* Islets of Langerhans / drug effects, physiology* Sodium / metabolism, pharmacology Sodium-Hydrogen Antiporter |
| Grant Support | |
ID/Acronym/Agency:
|
AM-35449/AM/NIADDK NIH HHS; AM-35577/AM/NIADDK NIH HHS |
| Chemical | |
Reg. No./Substance:
|
0/Carrier Proteins; 0/Ion Channels; 0/Sodium-Hydrogen Antiporter; 11061-68-0/Insulin; 50-99-7/Glucose; 7440-23-5/Sodium |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Chemical and clinical studies of endogenous digitalis-like factor in hypertension.
Next Document: Oncogenes and phosphatidylinositol turnover.