| Transmembrane collagen XVII is a novel component of the glomerular filtration barrier. | |
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MedLine Citation:
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PMID: 22457199 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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The kidney filtration barrier consists of the capillary endothelium, the glomerular basement membrane and the slit diaphragm localized between foot processes of neighbouring podocytes. We report that collagen XVII, a transmembrane molecule known to be required for epithelial adhesion, is expressed in podocytes of normal human and mouse kidneys and in endothelial cells of the glomerular filtration barrier. Immunoelectron microscopy has revealed that collagen XVII is localized in foot processes of podocytes and in the glomerular basement membrane. Its role in kidney has been analysed in knockout mice, which survive to birth but have high neonatal mortality and skin blistering and structural abnormalities in their glomeruli. Morphometric analysis has shown increases in glomerular volume fraction and surface densities of knockout kidneys, indicating an increased glomerular amount in the cortex. Collagen XVII deficiency causes effacement of podocyte foot processes; however, major slit diaphragm disruptions have not been detected. The glomerular basement membrane is split in areas in which glomerular and endothelial basement membranes meet. Differences in the expression of collagen IV, integrins α3 or β1, laminin α5 and nephrin have not been observed in mutant mice compared with controls. We propose that collagen XVII has a function in the attachment of podocyte foot processes to the glomerular basement membrane. It probably contributes to podocyte maturation and might have a role in glomerular filtration. |
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Authors:
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Tiina Hurskainen; Jyri Moilanen; Raija Sormunen; Claus-Werner Franzke; Raija Soininen; Stefanie Loeffek; Laura Huilaja; Matti Nuutinen; Leena Bruckner-Tuderman; Helena Autio-Harmainen; Kaisa Tasanen |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-3-29 |
Journal Detail:
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Title: Cell and tissue research Volume: - ISSN: 1432-0878 ISO Abbreviation: - Publication Date: 2012 Mar |
Date Detail:
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Created Date: 2012-3-29 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0417625 Medline TA: Cell Tissue Res Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Department of Dermatology, Oulu Center for Cell-Matrix Research, University of Oulu, Aapistie 5A, FIN-90220, Oulu, Finland, tiina.hurskainen@oulu.fi. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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