Document Detail


Transluminal angioplasty in experimental atherosclerosis. Analysis for embolization using an in vivo perfusion system.
MedLine Citation:
PMID:  6215186     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We used polarized light microscopy and thin-layer chromatography to determine whether embolization of atherosclerotic material occurs after transluminal angioplasty. The experimental model consisted of an in vivo perfusion system of the atherosclerotic rabbit left iliac artery. Of eight rabbits that underwent successful angioplasty, four had angiographic evidence of dissection and three showed aneurysm formation. Histologic studies demonstrated fracture of the intimal plaque, dissection, and stretching of the noninvolved portion of the vessel. Perfusate analysis revealed no detectable cholesterol by thin-layer chromatography in six of eight rabbits. In two rabbits, a very small amount of cholesterol was measured, which was totally accounted for by hemorrhage into the perfusate rather than from cholesterol in the plaque. No evidence of arterial wall embolic debris could be detected by polarized light microscopy in seven rabbits, but lipid debris from the plaque was found in the perfusate of one rabbit that had excessive arterial trauma. We conclude that the major mechanism of successful transluminal angioplasty in this experimental model is intimal fracture combined with stretching of a noninvolved portion of the vessel. Furthermore, embolization of atheromatous lipid debris was an uncommon event related to arterial trauma during catheter placement rather than transluminal angioplasty itself.
Authors:
T A Sanborn; D P Faxon; D Waugh; D M Small; C Haudenschild; S B Gottsman; T J Ryan
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Circulation     Volume:  66     ISSN:  0009-7322     ISO Abbreviation:  Circulation     Publication Date:  1982 Nov 
Date Detail:
Created Date:  1982-12-16     Completed Date:  1982-12-16     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0147763     Medline TA:  Circulation     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  917-22     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Angioplasty, Balloon / adverse effects*
Animals
Arteriosclerosis / etiology,  pathology,  therapy*
Chromatography, Thin Layer
Diet, Atherogenic
Embolism / etiology*,  pathology
Iliac Artery
Male
Perfusion
Rabbits
Grant Support
ID/Acronym/Agency:
1 ROLNL27512-01//PHS HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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