| Translocator protein PET imaging for glial activation in multiple sclerosis. | |
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MedLine Citation:
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PMID: 20872081 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Glial activation in the setting of central nervous system inflammation is a key feature of the multiple sclerosis (MS) pathology. Monitoring glial activation in subjects with MS, therefore, has the potential to be informative with respect to disease activity. The translocator protein 18 kDa (TSPO) is a promising biomarker of glial activation that can be imaged by positron emission tomography (PET). To characterize the in vivo TSPO expression in MS, we analyzed brain PET scans in subjects with MS and healthy volunteers in an observational study using [(11)C]PBR28, a newly developed translocator protein-specific radioligand. The [(11)C]PBR28 PET showed altered compartmental distribution of TSPO in the MS brain compared to healthy volunteers (p = 0.019). Focal increases in [(11)C]PBR28 binding corresponded to areas of active inflammation as evidenced by significantly greater binding in regions of gadolinium contrast enhancement compared to contralateral normal-appearing white matter (p = 0.0039). Furthermore, increase in [(11)C]PBR28 binding preceded the appearance of contrast enhancement on magnetic resonance imaging in some lesions, suggesting a role for early glial activation in MS lesion formation. Global [(11)C]PBR28 binding showed correlation with disease duration (p = 0.041), but not with measures of clinical disability. These results further define TSPO as an informative marker of glial activation in MS. |
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Authors:
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Unsong Oh; Masahiro Fujita; Vasiliki N Ikonomidou; Iordanis E Evangelou; Eiji Matsuura; Erin Harberts; Yota Fujimura; Nancy D Richert; Joan Ohayon; Victor W Pike; Yi Zhang; Sami S Zoghbi; Robert B Innis; Steven Jacobson |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Intramural Date: 2010-09-25 |
Journal Detail:
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Title: Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology Volume: 6 ISSN: 1557-1904 ISO Abbreviation: J Neuroimmune Pharmacol Publication Date: 2011 Sep |
Date Detail:
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Created Date: 2011-07-01 Completed Date: 2011-09-30 Revised Date: 2012-01-16 |
Medline Journal Info:
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Nlm Unique ID: 101256586 Medline TA: J Neuroimmune Pharmacol Country: United States |
Other Details:
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Languages: eng Pagination: 354-61 Citation Subset: IM |
Affiliation:
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Neuroimmunology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, 10 Center Drive, Bldg 10 Rm 5C103, Bethesda, MD 20892, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Acetamides
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diagnostic use Adult Aged Biological Markers / analysis Carbon Radioisotopes / diagnostic use Female Humans Magnetic Resonance Imaging Male Middle Aged Multiple Sclerosis / immunology, pathology*, radionuclide imaging* Neuroglia / immunology, metabolism, pathology* Positron-Emission Tomography Pyridines / diagnostic use Radiopharmaceuticals / diagnostic use Receptors, GABA / biosynthesis* |
| Grant Support | |
ID/Acronym/Agency:
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ZIA MH002852-06/MH/NIMH NIH HHS; ZIA NS002853-18/NS/NINDS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Acetamides; 0/Biological Markers; 0/Carbon Radioisotopes; 0/N-(2-methoxybenzyl)-N-(4-phenoxypyridin-3-yl)acetamide; 0/Pyridines; 0/Radiopharmaceuticals; 0/Receptors, GABA; 0/TSPO protein, human |
| Comments/Corrections | |
Erratum In:
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J Neuroimmune Pharmacol. 2011 Sep;6(3):434 Note: Fujimura, Yota [added]; Richert, Nancy D [added] |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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