Document Detail


Translocation of proteins into mitochondria.
MedLine Citation:
PMID:  17263664     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
About 10% to 15% of the nuclear genes of eukaryotic organisms encode mitochondrial proteins. These proteins are synthesized in the cytosol and recognized by receptors on the surface of mitochondria. Translocases in the outer and inner membrane of mitochondria mediate the import and intramitochondrial sorting of these proteins; ATP and the membrane potential are used as energy sources. Chaperones and auxiliary factors assist in the folding and assembly of mitochondrial proteins into their native, three-dimensional structures. This review summarizes the present knowledge on the import and sorting of mitochondrial precursor proteins, with a special emphasis on unresolved questions and topics of current research.
Authors:
Walter Neupert; Johannes M Herrmann
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Annual review of biochemistry     Volume:  76     ISSN:  0066-4154     ISO Abbreviation:  Annu. Rev. Biochem.     Publication Date:  2007  
Date Detail:
Created Date:  2007-06-20     Completed Date:  2007-09-17     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  2985150R     Medline TA:  Annu Rev Biochem     Country:  United States    
Other Details:
Languages:  eng     Pagination:  723-49     Citation Subset:  IM    
Affiliation:
Institut für Physiologische Chemie, Universität München, 81377 München, Germany. neupert@med.uni-muenchen.de
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MeSH Terms
Descriptor/Qualifier:
Animals
Carrier Proteins / chemistry,  metabolism,  ultrastructure
Humans
Membrane Proteins / chemistry,  genetics,  metabolism
Membrane Transport Proteins / chemistry,  metabolism
Mitochondria / metabolism*
Mitochondrial Membrane Transport Proteins
Mitochondrial Proteins / chemistry,  genetics,  metabolism*
Protein Precursors / genetics,  metabolism*
Protein Sorting Signals
Protein Transport / physiology*
Saccharomyces cerevisiae Proteins / chemistry,  metabolism
Chemical
Reg. No./Substance:
0/Carrier Proteins; 0/MAS6 protein, S cerevisiae; 0/Membrane Proteins; 0/Membrane Transport Proteins; 0/Mitochondrial Membrane Transport Proteins; 0/Mitochondrial Proteins; 0/Protein Precursors; 0/Protein Sorting Signals; 0/Saccharomyces cerevisiae Proteins; 0/TIM22 protein, S cerevisiae; 0/TOM translocase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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