| Translocation of proteins across the mitochondrial inner membrane, but not into the outer membrane, requires nucleoside triphosphates in the matrix. | |
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MedLine Citation:
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PMID: 2554316 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Work in several laboratories has established that import of proteins across the mitochondrial inner membrane requires an electrochemical potential across that membrane and cleavage of nucleoside triphosphate. We now show that nucleoside triphosphate must be present inside the inner membrane. In contrast, the potential-independent insertion of porin into the outer membrane requires ATP only outside the inner membrane. |
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Authors:
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S T Hwang; G Schatz |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Proceedings of the National Academy of Sciences of the United States of America Volume: 86 ISSN: 0027-8424 ISO Abbreviation: Proc. Natl. Acad. Sci. U.S.A. Publication Date: 1989 Nov |
Date Detail:
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Created Date: 1989-12-08 Completed Date: 1989-12-08 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 7505876 Medline TA: Proc Natl Acad Sci U S A Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 8432-6 Citation Subset: IM |
Affiliation:
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Biocenter, University of Basel, Switzerland. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adenosine Triphosphate
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metabolism Bacterial Outer Membrane Proteins / metabolism Guanosine Triphosphate / metabolism Intracellular Membranes / drug effects, metabolism* L-Lactate Dehydrogenase / metabolism L-Lactate Dehydrogenase (Cytochrome) Mitochondria / metabolism* Porins Potassium Cyanide / pharmacology Proteins / metabolism* Recombinant Fusion Proteins / metabolism Ribonucleotides / metabolism* Saccharomyces cerevisiae / metabolism* Tetrahydrofolate Dehydrogenase / genetics, metabolism Valinomycin / pharmacology |
| Grant Support | |
ID/Acronym/Agency:
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CBY-11 ROI GM 37803/GM/NIGMS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Bacterial Outer Membrane Proteins; 0/Porins; 0/Proteins; 0/Recombinant Fusion Proteins; 0/Ribonucleotides; 151-50-8/Potassium Cyanide; 2001-95-8/Valinomycin; 56-65-5/Adenosine Triphosphate; 86-01-1/Guanosine Triphosphate; EC 1.1.1.27/L-Lactate Dehydrogenase; EC 1.1.2.3/L-Lactate Dehydrogenase (Cytochrome); EC 1.5.1.3/Tetrahydrofolate Dehydrogenase |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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