Document Detail


Translocation of proteins across the mitochondrial inner membrane, but not into the outer membrane, requires nucleoside triphosphates in the matrix.
MedLine Citation:
PMID:  2554316     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Work in several laboratories has established that import of proteins across the mitochondrial inner membrane requires an electrochemical potential across that membrane and cleavage of nucleoside triphosphate. We now show that nucleoside triphosphate must be present inside the inner membrane. In contrast, the potential-independent insertion of porin into the outer membrane requires ATP only outside the inner membrane.
Authors:
S T Hwang; G Schatz
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Proceedings of the National Academy of Sciences of the United States of America     Volume:  86     ISSN:  0027-8424     ISO Abbreviation:  Proc. Natl. Acad. Sci. U.S.A.     Publication Date:  1989 Nov 
Date Detail:
Created Date:  1989-12-08     Completed Date:  1989-12-08     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  7505876     Medline TA:  Proc Natl Acad Sci U S A     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  8432-6     Citation Subset:  IM    
Affiliation:
Biocenter, University of Basel, Switzerland.
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MeSH Terms
Descriptor/Qualifier:
Adenosine Triphosphate / metabolism
Bacterial Outer Membrane Proteins / metabolism
Guanosine Triphosphate / metabolism
Intracellular Membranes / drug effects,  metabolism*
L-Lactate Dehydrogenase / metabolism
L-Lactate Dehydrogenase (Cytochrome)
Mitochondria / metabolism*
Porins
Potassium Cyanide / pharmacology
Proteins / metabolism*
Recombinant Fusion Proteins / metabolism
Ribonucleotides / metabolism*
Saccharomyces cerevisiae / metabolism*
Tetrahydrofolate Dehydrogenase / genetics,  metabolism
Valinomycin / pharmacology
Grant Support
ID/Acronym/Agency:
CBY-11 ROI GM 37803/GM/NIGMS NIH HHS
Chemical
Reg. No./Substance:
0/Bacterial Outer Membrane Proteins; 0/Porins; 0/Proteins; 0/Recombinant Fusion Proteins; 0/Ribonucleotides; 151-50-8/Potassium Cyanide; 2001-95-8/Valinomycin; 56-65-5/Adenosine Triphosphate; 86-01-1/Guanosine Triphosphate; EC 1.1.1.27/L-Lactate Dehydrogenase; EC 1.1.2.3/L-Lactate Dehydrogenase (Cytochrome); EC 1.5.1.3/Tetrahydrofolate Dehydrogenase
Comments/Corrections

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