Document Detail


Translocation (2;13) and other chromosome abnormalities in intraosseous schwannoma of the mandible.
MedLine Citation:
PMID:  19665074     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Intraosseous schwannoma is rare, and most commonly occurs in the mandible. Benign classic schwannomas commonly carry normal karyotypes admixed with aberrant near-diploid karyotypes with a few simple clonal chromosome changes, mainly numerical. No consistent chromosomal aberrations have been observed so far. It is unclear whether the chromosomal abnormalities are affected by the anatomic site of the tumor; however, we know of no cytogenetic reports on schwannoma in the oral area. This novel report of cytogenetic analysis of intraosseous schwannoma represents the fifth report on a new balanced translocation in schwannoma in general. We identified clonal t(2;13) in an intraosseous schwannoma of the mandible. The significance of t(2;13) in diagnosis or prognosis is not yet clear, and should be further examined by karyotyping of more schwannoma cases.
Authors:
Esther Manor; Sarit Tetro; Monica Noyhous; Palina Kachko; Lipa Bodner
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Cancer genetics and cytogenetics     Volume:  193     ISSN:  1873-4456     ISO Abbreviation:  Cancer Genet. Cytogenet.     Publication Date:  2009 Sep 
Date Detail:
Created Date:  2009-08-11     Completed Date:  2009-09-01     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7909240     Medline TA:  Cancer Genet Cytogenet     Country:  United States    
Other Details:
Languages:  eng     Pagination:  116-8     Citation Subset:  IM    
Affiliation:
Genetic Institute, Soroka University Medical Center, Faculty of Health Sciences, Ben Gurion University of the Negev, P.O. Box 151 Beer-Sheva 84101, Israel. manore@bgu.ac.il
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MeSH Terms
Descriptor/Qualifier:
Chromosomes, Human, Pair 13*
Chromosomes, Human, Pair 2*
Female
Humans
Jaw Neoplasms / genetics*
Karyotyping
Middle Aged
Neurilemmoma / genetics*
Translocation, Genetic*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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