Document Detail


Translocation (6;17)(q23;q11.2): a novel cytogenetic abnormality in congenital acute myeloid leukemia?
MedLine Citation:
PMID:  16271959     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Congenital leukemia occurring within 4 weeks of birth is extremely rare and, excluding transient neonatal myeloproliferation associated with Down syndrome, makes up approximately 1% of childhood leukemias. It is usually seen as acute myeloid leukemia (AML), most frequently French-American-British (FAB) types M4 and M5. Recurrent cytogenetic abnormalities have been reported in this group, and in approximately one third of cases the MLL gene at 11q23 is involved. These patients generally have a poor prognosis. We present a case of congenital leukemia (AML FAB type M1) with an acquired translocation between chromosomes 6 and 17.
Authors:
Elspeth C Ferguson; Polly Talley; Ajay Vora
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Cancer genetics and cytogenetics     Volume:  163     ISSN:  0165-4608     ISO Abbreviation:  Cancer Genet. Cytogenet.     Publication Date:  2005 Nov 
Date Detail:
Created Date:  2005-11-07     Completed Date:  2006-01-23     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7909240     Medline TA:  Cancer Genet Cytogenet     Country:  United States    
Other Details:
Languages:  eng     Pagination:  71-3     Citation Subset:  IM    
Affiliation:
Department of Pediatric Haematology and North Trent Cytogenetics Service, Sheffield Children's Hospital, Western Bank, Sheffield S10 2TH, United Kingdom.
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MeSH Terms
Descriptor/Qualifier:
Chromosome Mapping
Chromosomes, Human, Pair 17*
Chromosomes, Human, Pair 6*
Fatal Outcome
Humans
Infant, Newborn
Infant, Premature
Leukemia, Myeloid, Acute / blood,  congenital,  genetics*
Male
Translocation, Genetic*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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