| Translocation t(14;16) and multiple myeloma: is it really an independent prognostic factor? | |
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MedLine Citation:
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PMID: 20962323 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Many trials in myeloma are stratified on cytogenetic abnormalities. Among them, the most commonly chosen are the t(4;14), the del(17p), and the t(14;16). If data are well established for t(4;14) and del(17p), very few data support the use of t(14;16). To address this issue, we retrospectively analyzed 1003 patients with newly diagnosed myeloma for this abnormality. We identified 32 patients with the t(14;16). Compared with patients lacking the t(14;16), we did not observe any difference in overall survival (P = .28). Moreover, in multivariate analyses, the t(14;16) was not prognostic (P = .39). In conclusion, our data do not support the use of t(14;16)-specific probes in the diagnostic panels of multiple myeloma. |
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Authors:
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Hervé Avet-Loiseau; Florent Malard; Loic Campion; Florence Magrangeas; Catherine Sebban; Bruno Lioure; Olivier Decaux; Thierry Lamy; Laurence Legros; Jean-Gabriel Fuzibet; Mauricette Michallet; Bernadette Corront; Pascal Lenain; Cyrille Hulin; Claire Mathiot; Michel Attal; Thierry Facon; Jean-Luc Harousseau; Stephane Minvielle; Philippe Moreau; |
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Publication Detail:
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Type: Journal Article Date: 2010-10-20 |
Journal Detail:
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Title: Blood Volume: 117 ISSN: 1528-0020 ISO Abbreviation: Blood Publication Date: 2011 Feb |
Date Detail:
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Created Date: 2011-02-11 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7603509 Medline TA: Blood Country: United States |
Other Details:
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Languages: eng Pagination: 2009-11 Citation Subset: AIM; IM |
Affiliation:
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Hematology Laboratory, University Hospital, and Inserm U892, Nantes, France. havetloiseau@chu-nantes.fr |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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