Document Detail


Translocation t(14;16) and multiple myeloma: is it really an independent prognostic factor?
MedLine Citation:
PMID:  20962323     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Many trials in myeloma are stratified on cytogenetic abnormalities. Among them, the most commonly chosen are the t(4;14), the del(17p), and the t(14;16). If data are well established for t(4;14) and del(17p), very few data support the use of t(14;16). To address this issue, we retrospectively analyzed 1003 patients with newly diagnosed myeloma for this abnormality. We identified 32 patients with the t(14;16). Compared with patients lacking the t(14;16), we did not observe any difference in overall survival (P = .28). Moreover, in multivariate analyses, the t(14;16) was not prognostic (P = .39). In conclusion, our data do not support the use of t(14;16)-specific probes in the diagnostic panels of multiple myeloma.
Authors:
Hervé Avet-Loiseau; Florent Malard; Loic Campion; Florence Magrangeas; Catherine Sebban; Bruno Lioure; Olivier Decaux; Thierry Lamy; Laurence Legros; Jean-Gabriel Fuzibet; Mauricette Michallet; Bernadette Corront; Pascal Lenain; Cyrille Hulin; Claire Mathiot; Michel Attal; Thierry Facon; Jean-Luc Harousseau; Stephane Minvielle; Philippe Moreau;
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Publication Detail:
Type:  Journal Article     Date:  2010-10-20
Journal Detail:
Title:  Blood     Volume:  117     ISSN:  1528-0020     ISO Abbreviation:  Blood     Publication Date:  2011 Feb 
Date Detail:
Created Date:  2011-02-11     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7603509     Medline TA:  Blood     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2009-11     Citation Subset:  AIM; IM    
Affiliation:
Hematology Laboratory, University Hospital, and Inserm U892, Nantes, France. havetloiseau@chu-nantes.fr
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