Document Detail


Translocation (10;11)(p12;q23) in childhood acute myeloid leukemia: incidence and complex mechanism.
MedLine Citation:
PMID:  16938568     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Using both conventional and molecular cytogenetic methods, we found five new cases of t(10;11)(p12;q23). This translocation represented 28% of all cases of childhood AML treated at our center in 2004, and 63% of AML with rearrangements of 11q23. We describe three mechanisms for the translocation. Different fragments of 11q were involved in four of the five cases. One patient showed a cytogenetically cryptic insertion of 5' part of MLL into the 3' part of MLLT10 in 10p12. The median event-free survival of patients was 8.1 months, and we conclude that the t(10;11)(p12;q23) is associated with unfavorable prognosis in childhood acute myeloid leukemia.
Authors:
Irina Stasevich; Regina Utskevich; Anatoly Kustanovich; Natallia Litvinko; Tatsiana Savitskaya; Svetlana Chernyavskaya; Olga Saharova; Olga Aleinikova
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Cancer genetics and cytogenetics     Volume:  169     ISSN:  0165-4608     ISO Abbreviation:  Cancer Genet. Cytogenet.     Publication Date:  2006 Sep 
Date Detail:
Created Date:  2006-08-29     Completed Date:  2006-10-30     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7909240     Medline TA:  Cancer Genet Cytogenet     Country:  United States    
Other Details:
Languages:  eng     Pagination:  114-20     Citation Subset:  IM    
Affiliation:
Research Center for Pediatric Oncology and Hematology, 223040, Minsk Region, p. Lesnoi, Belarus. istasevich@yahoo.com
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MeSH Terms
Descriptor/Qualifier:
Acute Disease
Adolescent
Child
Child, Preschool
Chromosome Banding
Chromosomes, Human, Pair 10*
Chromosomes, Human, Pair 11*
Female
Humans
In Situ Hybridization, Fluorescence
Infant
Karyotyping
Leukemia, Myeloid / genetics*
Male
Reverse Transcriptase Polymerase Chain Reaction
Translocation, Genetic*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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