Document Detail


Translocation of gut flora and its role in sepsis.
MedLine Citation:
PMID:  24064638     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Bacterial translocation is the invasion of indigenous intestinal bacteria through the gut mucosa to normally sterile tissues and the internal organs. Sometimes instead of bacteria, inflammatory compounds are responsible for clinical symptoms as in systemic inflammatory response syndrome (SIRS). The difference between sepsis and SIRS is that pathogenic bacteria are isolated from patients with sepsis but not with those of SIRS. Bacterial translocation occurs more frequently in patients with intestinal obstruction and in immunocompromised patients and is the cause of subsequent sepsis. Factors that can trigger bacterial translocation from the gut are host immune deficiencies and immunosuppression, disturbances in normal ecological balance of gut, mucosal barrier permeability, obstructive jaundice, stress, etc. Bacterial translocation occurs through the transcellular and the paracellular pathways and can be measured both directly by culture of mesenteric lymph nodes and indirectly by using labeled bacteria, peripheral blood culture, detection of microbial DNA or endotoxin and urinary excretion of non-metabolisable sugars. Bacterial translocation may be a normal phenomenon occurring on frequent basis in healthy individuals without any deleterious consequences. But when the immune system is challenged extensively, it breaks down and results in septic complications at different sites away from the main focus. The factors released from the gut and carried in the mesenteric lymphatics but not in the portal blood are enough to cause multi-organ failure. Thus, bacterial translocation may be a promoter of sepsis but not the initiator. This paper reviews literature on the translocation of gut flora and its role in causing sepsis.
Authors:
C Vaishnavi
Related Documents :
24700868 - Spleen tyrosine kinase inhibition attenuates autoantibody production and reverses exper...
23702978 - Activation and regulation of the inflammasomes.
23507938 - Role of calpain in apoptosis.
23347398 - Innate immune markers that distinguish red deer (cervus elaphus) selected for resistant...
16497588 - Pathogen recognition and innate immunity.
15852018 - Ceramide upregulation causes pulmonary cell apoptosis and emphysema-like disease in mice.
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Indian journal of medical microbiology     Volume:  31     ISSN:  1998-3646     ISO Abbreviation:  Indian J Med Microbiol     Publication Date:    2013 Oct-Dec
Date Detail:
Created Date:  2013-09-25     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8700903     Medline TA:  Indian J Med Microbiol     Country:  India    
Other Details:
Languages:  eng     Pagination:  334-42     Citation Subset:  IM    
Affiliation:
Department of Gastroenterology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Evidence for oxygen use in the hospitalized patient: is more really the enemy of good?
Next Document:  First case series of emerging Rickettsial neonatal sepsis identified by polymerase chain reaction-ba...