Document Detail

Translocation (2;3)(p22;q28) is associated with myeloid disorders.
MedLine Citation:
PMID:  7889504     Owner:  NLM     Status:  MEDLINE    
Chromosome studies carried out in two children with acute myeloblastic leukemia (AML, M2) showed a t(2;3)(p22;q28). This abnormality was associated with monosomy 7 and del(12)(p12) in the first patient and was found only in relapse in the second patient. Comparison with the other previously published t(2;3) suggests that this translocation is a nonrandom abnormality involving a pluripotent stem cell and occurring as a secondary chromosome abnormality in AML.
R Berger; M Flexor; M Le Coniat; J Derré; T Leblanc
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Cancer genetics and cytogenetics     Volume:  79     ISSN:  0165-4608     ISO Abbreviation:  Cancer Genet. Cytogenet.     Publication Date:  1995 Feb 
Date Detail:
Created Date:  1995-04-20     Completed Date:  1995-04-20     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7909240     Medline TA:  Cancer Genet Cytogenet     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  130-2     Citation Subset:  IM    
INSERM U 301, Institut de Génétique Moléculaire, Paris, France.
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MeSH Terms
Child, Preschool
Chromosomes, Human, Pair 2*
Chromosomes, Human, Pair 3*
Leukemia, Myeloid, Acute / genetics*
Translocation, Genetic*
Comment In:
Cancer Genet Cytogenet. 1996 Aug;90(1):93   [PMID:  8780757 ]

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