Document Detail

Translocation (8;14)(q24;q32) as the sole cytogenetic abnormality in B-cell prolymphocytic leukemia.
MedLine Citation:
PMID:  15066324     Owner:  NLM     Status:  MEDLINE    
B-cell prolymphocytic leukemia is a relatively rare lymphoproliferative disorder. No specific cytogenetic abnormality has yet been associated with it. The most common translocation reported in patients with this disease is t(11;14)(q13;q32). We describe the case of a patient with B-cell prolymphocytic leukemia and a hitherto unreported genetic translocation (8;14)(q24;q32) as the sole genetic abnormality, classically seen in patients with B-cell acute lymphoblastic leukemia/Burkitt lymphoma. This patient presented with an asymptomatic leukocytosis and splenomegaly. Her marrow showed lymphoid hyperplasia, with immunophenotyping consistent with prolymphocytic leukemia; however, t(8;14)(q24;q32) was the only cytogenetic aberration with both standard karyotyping and fluorescence in situ hybridization analysis.
Philip Kuriakose; Nusrat Perveen; Koichi Maeda; Anne Wiktor; Daniel L Van Dyke
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Cancer genetics and cytogenetics     Volume:  150     ISSN:  0165-4608     ISO Abbreviation:  Cancer Genet. Cytogenet.     Publication Date:  2004 Apr 
Date Detail:
Created Date:  2004-04-06     Completed Date:  2004-06-30     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7909240     Medline TA:  Cancer Genet Cytogenet     Country:  United States    
Other Details:
Languages:  eng     Pagination:  156-8     Citation Subset:  IM    
Department of Internal Medicine, Division of Hematology/Oncology, Henry Ford Hospital, 2799 West Grand Boulevard, Detroit, MI 48202, USA.
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MeSH Terms
Bone Marrow / pathology
Chromosome Mapping
Chromosomes, Human, Pair 14 / genetics*
Chromosomes, Human, Pair 8 / genetics*
In Situ Hybridization, Fluorescence
Leukemia, B-Cell / genetics*,  pathology
Leukemia, Prolymphocytic / genetics*,  pathology
Translocation, Genetic / genetics*

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