| Translocation (8;14)(q24;q32) as the sole cytogenetic abnormality in B-cell prolymphocytic leukemia. | |
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MedLine Citation:
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PMID: 15066324 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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B-cell prolymphocytic leukemia is a relatively rare lymphoproliferative disorder. No specific cytogenetic abnormality has yet been associated with it. The most common translocation reported in patients with this disease is t(11;14)(q13;q32). We describe the case of a patient with B-cell prolymphocytic leukemia and a hitherto unreported genetic translocation (8;14)(q24;q32) as the sole genetic abnormality, classically seen in patients with B-cell acute lymphoblastic leukemia/Burkitt lymphoma. This patient presented with an asymptomatic leukocytosis and splenomegaly. Her marrow showed lymphoid hyperplasia, with immunophenotyping consistent with prolymphocytic leukemia; however, t(8;14)(q24;q32) was the only cytogenetic aberration with both standard karyotyping and fluorescence in situ hybridization analysis. |
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Authors:
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Philip Kuriakose; Nusrat Perveen; Koichi Maeda; Anne Wiktor; Daniel L Van Dyke |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Cancer genetics and cytogenetics Volume: 150 ISSN: 0165-4608 ISO Abbreviation: Cancer Genet. Cytogenet. Publication Date: 2004 Apr |
Date Detail:
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Created Date: 2004-04-06 Completed Date: 2004-06-30 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 7909240 Medline TA: Cancer Genet Cytogenet Country: United States |
Other Details:
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Languages: eng Pagination: 156-8 Citation Subset: IM |
Affiliation:
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Department of Internal Medicine, Division of Hematology/Oncology, Henry Ford Hospital, 2799 West Grand Boulevard, Detroit, MI 48202, USA. pkuriak1@hfhs.org |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Bone Marrow / pathology Chromosome Mapping Chromosomes, Human, Pair 14 / genetics* Chromosomes, Human, Pair 8 / genetics* Female Humans In Situ Hybridization, Fluorescence Karyotyping Leukemia, B-Cell / genetics*, pathology Leukemia, Prolymphocytic / genetics*, pathology Translocation, Genetic / genetics* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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