Document Detail

Translocation (15;17)(q22;q21) as a secondary chromosomal abnormality in a case of acute monoblastic leukemia with tetrasomy 8.
MedLine Citation:
PMID:  10459339     Owner:  NLM     Status:  MEDLINE    
We describe a case of acute monoblastic leukemia (AML M5a), originally presenting as granulocytic sarcoma of the testis, showing unusual cytogenetic abnormalities. Tetrasomy 8 (primary) and t(15;17)(q22;q21) (secondary) were detected in bone marrow cells 6 months post-diagnosis, both by routine karyotype analysis and by fluorescence in situ hybridization (FISH) studies on metaphases and interphase nuclei. Retrospectively, the same abnormalities were identified in the primary testicular lesion using interphase FISH. However, reverse transcriptase polymerase chain reaction (RT-PCR) did not reveal the presence of a classic PML/RAR alpha fusion transcript. To the best of our knowledge, this is the first case to be reported in the literature of AML showing tetrasomy 8 in combination with secondary t(15;17).
X X Zhang; L J Robinson; T T Stenzel; M B Qumsiyeh
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Cancer genetics and cytogenetics     Volume:  113     ISSN:  0165-4608     ISO Abbreviation:  Cancer Genet. Cytogenet.     Publication Date:  1999 Aug 
Date Detail:
Created Date:  1999-09-10     Completed Date:  1999-09-10     Revised Date:  2006-09-29    
Medline Journal Info:
Nlm Unique ID:  7909240     Medline TA:  Cancer Genet Cytogenet     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  9-13     Citation Subset:  IM    
Department of Pathology, Duke University Medical Center, Durham, NC 27710, USA.
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MeSH Terms
Chromosome Banding
Chromosomes, Human, Pair 15*
Chromosomes, Human, Pair 17*
Chromosomes, Human, Pair 8*
In Situ Hybridization, Fluorescence
Leukemia, Monocytic, Acute / genetics*
Middle Aged
Neoplasm Proteins / genetics
Oncogene Proteins, Fusion / genetics
Reverse Transcriptase Polymerase Chain Reaction
Sarcoma / genetics
Testicular Neoplasms / genetics
Translocation, Genetic*
Reg. No./Substance:
0/Neoplasm Proteins; 0/Oncogene Proteins, Fusion; 0/promyelocytic leukemia-retinoic acid receptor alpha fusion oncoprotein

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