Document Detail

Translocation of C60 and its derivatives across a lipid bilayer.
MedLine Citation:
PMID:  17316055     Owner:  NLM     Status:  MEDLINE    
Obtaining an understanding, at the atomic level, of the interaction of nanomaterials with biological systems has recently become an issue of great research interest. Here we report on the molecular dynamics study of the translocation of fullerene C60 and its derivative C60(OH)20 across a model cell membrane (dipalmitoylphosphatidylcholine or DPPC bilayer). The simulation results indicate that, although a pristine C60 molecule can readily "jump" into the bilayer and translocate the membrane within a few milliseconds, the C60(OH)20 molecule can barely penetrate the bilayer. Indeed, the mean translocation time via diffusion for the C60(OH)20 molecule is several orders of magnitude longer than for the former. It was also determined that the two different forms of fullerenes, when adsorbed into/onto the bilayer, affected the membrane structure differently. This study offers a mechanistic explanation of that difference and for the reduced acute toxicity of functionalized fullerenes.
Rui Qiao; Aaron P Roberts; Andrew S Mount; Stephen J Klaine; Pu Chun Ke
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.     Date:  2007-02-23
Journal Detail:
Title:  Nano letters     Volume:  7     ISSN:  1530-6984     ISO Abbreviation:  Nano Lett.     Publication Date:  2007 Mar 
Date Detail:
Created Date:  2007-03-14     Completed Date:  2007-04-18     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101088070     Medline TA:  Nano Lett     Country:  United States    
Other Details:
Languages:  eng     Pagination:  614-9     Citation Subset:  IM    
Department of Mechanical Engineering, Clemson University, Clemson, South Carolina 29634, USA.
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MeSH Terms
1,2-Dipalmitoylphosphatidylcholine / chemistry,  metabolism
Biological Transport, Active
Fullerenes / pharmacokinetics*
Lipid Bilayers / chemistry,  metabolism*
Models, Biological
Models, Molecular
Nanoparticles / chemistry*
Reg. No./Substance:
0/Fullerenes; 0/Lipid Bilayers; 2644-64-6/1,2-Dipalmitoylphosphatidylcholine; 99685-96-8/fullerene C60

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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