Document Detail


Translocation of C60 and its derivatives across a lipid bilayer.
MedLine Citation:
PMID:  17316055     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Obtaining an understanding, at the atomic level, of the interaction of nanomaterials with biological systems has recently become an issue of great research interest. Here we report on the molecular dynamics study of the translocation of fullerene C60 and its derivative C60(OH)20 across a model cell membrane (dipalmitoylphosphatidylcholine or DPPC bilayer). The simulation results indicate that, although a pristine C60 molecule can readily "jump" into the bilayer and translocate the membrane within a few milliseconds, the C60(OH)20 molecule can barely penetrate the bilayer. Indeed, the mean translocation time via diffusion for the C60(OH)20 molecule is several orders of magnitude longer than for the former. It was also determined that the two different forms of fullerenes, when adsorbed into/onto the bilayer, affected the membrane structure differently. This study offers a mechanistic explanation of that difference and for the reduced acute toxicity of functionalized fullerenes.
Authors:
Rui Qiao; Aaron P Roberts; Andrew S Mount; Stephen J Klaine; Pu Chun Ke
Related Documents :
22820065 - The toolbox of vesicle sidedness determination.
15291545 - Studying lateral diffusion in lipid bilayers by combining a magic angle spinning nmr pr...
18691565 - Nmr-based molecular ruler for determining the depth of intercalants within the lipid bi...
11332895 - Fabrication and photoelectric properties of self-assembled bilayer lipid membranes on c...
2001005 - Intestinal glycyl-l-phenylalanine and l-phenylalanine transport in a euryhaline teleost.
20345295 - Life table analysis for immatures and female adults of the predatory beetle, delphastus...
Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.     Date:  2007-02-23
Journal Detail:
Title:  Nano letters     Volume:  7     ISSN:  1530-6984     ISO Abbreviation:  Nano Lett.     Publication Date:  2007 Mar 
Date Detail:
Created Date:  2007-03-14     Completed Date:  2007-04-18     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101088070     Medline TA:  Nano Lett     Country:  United States    
Other Details:
Languages:  eng     Pagination:  614-9     Citation Subset:  IM    
Affiliation:
Department of Mechanical Engineering, Clemson University, Clemson, South Carolina 29634, USA. rqiao@ces.clemson.edu
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
1,2-Dipalmitoylphosphatidylcholine / chemistry,  metabolism
Biological Transport, Active
Fullerenes / pharmacokinetics*
Lipid Bilayers / chemistry,  metabolism*
Models, Biological
Models, Molecular
Nanoparticles / chemistry*
Chemical
Reg. No./Substance:
0/Fullerenes; 0/Lipid Bilayers; 2644-64-6/1,2-Dipalmitoylphosphatidylcholine; 99685-96-8/fullerene C60

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Effect of nanoscale curvature of single-walled carbon nanotubes on adsorption of polycyclic aromatic...
Next Document:  Metal-diboride nanotubes as high-capacity hydrogen storage media.