Document Detail


Translocation (5; 11) in a conjunctival MALT lymphoma.
MedLine Citation:
PMID:  22076174     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Lymphoma is the most frequent malignant tumor of the ocular adnexa with the most common histologic type being extranodal marginal zone B-cell lymphoma (EMZL) of mucosa-associated lymphoid tissue (MALT lymphoma). Here we report a case of a 28 year-old male who presented with a left conjunctival mass of one year duration. A diagnosis of primary MALT lymphoma of the conjunctiva was made based on morphologic and immunopheno-typic studies. Chromosome analysis revealed a male karyotype with a translocation t (5;11) (q33;p11.2) as the primary chromosomal abnormality, which, to the best of our knowledge, is the first reported translocation in MALT lym-phomas and ocular MALT lymphomas as well.
Authors:
Cecilia G Clement; Venkateswara R Potluri; John Gonzales; You-Wen Qian
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Publication Detail:
Type:  Case Reports; Journal Article     Date:  2011-09-30
Journal Detail:
Title:  International journal of clinical and experimental pathology     Volume:  4     ISSN:  1936-2625     ISO Abbreviation:  Int J Clin Exp Pathol     Publication Date:  2011  
Date Detail:
Created Date:  2011-11-14     Completed Date:  2012-03-02     Revised Date:  2013-06-27    
Medline Journal Info:
Nlm Unique ID:  101480565     Medline TA:  Int J Clin Exp Pathol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  722-6     Citation Subset:  IM    
Affiliation:
Departments of Pathology, University of Texas Medical Branch, Galveston, USA.
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MeSH Terms
Descriptor/Qualifier:
Adult
Chromosomes, Human, Pair 11*
Chromosomes, Human, Pair 5*
Conjunctival Neoplasms / chemistry,  genetics*,  pathology
Humans
Immunohistochemistry
Karyotyping
Lymphoma, B-Cell, Marginal Zone / chemistry,  genetics*,  pathology
Male
Translocation, Genetic*
Tumor Markers, Biological / analysis
Chemical
Reg. No./Substance:
0/Tumor Markers, Biological
Comments/Corrections

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