Document Detail

Translational research into sexual disorders: pharmacology and genomics.
MedLine Citation:
PMID:  18423444     Owner:  NLM     Status:  MEDLINE    
The existence of sexual dysfunctions in men, including premature and retarded ejaculation poses challenges to develop translational models in rats that may help in improving treatment and delineate the neural mechanisms of action. Most of our current understanding of the neurobiology, neuroanatomy and psychopharmacology of sexual behavior and ejaculatory function has been derived from preclinical studies in the rat. When large populations of male rats are tested on sexual activity during four successive tests, over time individual rats display a very stable sexual behavior that is either slow, normal or fast as characterized by the number of ejaculations performed. These sexual endophenotypes are postulated as rat counterparts of premature (fast rats) or retarded ejaculation (slow rats). Psychopharmacology in these endophenotypes may help to delineate the underlying mechanisms and pathology. This is illustrated by the effects of serotonergic antidepressants and serotonergic compounds on sexual and ejaculatory behavior of rats. Further unravelling of sexual endophenotypes may benefit from the use of chromosomal substitution strains in mice that enable the localization of relevant chromosomal areas and genes involved in ejaculation processes. These preclinical studies and models contribute to a better understanding of the neurobiology of ejaculation and boost the development of novel drug targets to treat ejaculatory disorders such as premature and retarded ejaculation.
Johnny S W Chan; Berend Olivier; Trynke R de Jong; Eelke M S Snoeren; Elke Kooijman; Felisa N van Hasselt; Jules H W Limpens; Martien J H Kas; Marcel D Waldinger; Ronald S Oosting
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Publication Detail:
Type:  Journal Article; Review     Date:  2008-03-18
Journal Detail:
Title:  European journal of pharmacology     Volume:  585     ISSN:  0014-2999     ISO Abbreviation:  Eur. J. Pharmacol.     Publication Date:  2008 May 
Date Detail:
Created Date:  2008-04-25     Completed Date:  2008-07-18     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  1254354     Medline TA:  Eur J Pharmacol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  426-35     Citation Subset:  IM    
Department of Psychopharmacology, Utrecht Institute of Pharmacological Sciences and Rudolf Magnus Institute of Neuroscience, Utrecht University, Utrecht, The Netherlands. address:
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MeSH Terms
Antidepressive Agents / adverse effects,  pharmacology
Ejaculation / drug effects
Serotonin / physiology
Serotonin Uptake Inhibitors / adverse effects,  pharmacology
Sexual Behavior, Animal / drug effects
Sexual Dysfunction, Physiological / chemically induced,  drug therapy*,  genetics*
Sexual Dysfunctions, Psychological / drug therapy*,  genetics*
Reg. No./Substance:
0/Antidepressive Agents; 0/Serotonin Uptake Inhibitors; 50-67-9/Serotonin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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