Document Detail


Translational research into sexual disorders: pharmacology and genomics.
MedLine Citation:
PMID:  18423444     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The existence of sexual dysfunctions in men, including premature and retarded ejaculation poses challenges to develop translational models in rats that may help in improving treatment and delineate the neural mechanisms of action. Most of our current understanding of the neurobiology, neuroanatomy and psychopharmacology of sexual behavior and ejaculatory function has been derived from preclinical studies in the rat. When large populations of male rats are tested on sexual activity during four successive tests, over time individual rats display a very stable sexual behavior that is either slow, normal or fast as characterized by the number of ejaculations performed. These sexual endophenotypes are postulated as rat counterparts of premature (fast rats) or retarded ejaculation (slow rats). Psychopharmacology in these endophenotypes may help to delineate the underlying mechanisms and pathology. This is illustrated by the effects of serotonergic antidepressants and serotonergic compounds on sexual and ejaculatory behavior of rats. Further unravelling of sexual endophenotypes may benefit from the use of chromosomal substitution strains in mice that enable the localization of relevant chromosomal areas and genes involved in ejaculation processes. These preclinical studies and models contribute to a better understanding of the neurobiology of ejaculation and boost the development of novel drug targets to treat ejaculatory disorders such as premature and retarded ejaculation.
Authors:
Johnny S W Chan; Berend Olivier; Trynke R de Jong; Eelke M S Snoeren; Elke Kooijman; Felisa N van Hasselt; Jules H W Limpens; Martien J H Kas; Marcel D Waldinger; Ronald S Oosting
Related Documents :
142244 - Effect of two brain serotonin depletors on the sexual behavior of male rats.
20927644 - Epilepsy and tsc2 haploinsufficiency lead to autistic-like social deficit behaviors in ...
6314984 - The modulation of the dorsal immobility response in the adult male wistar rat: the oppo...
3158004 - Altered responses to serotonergic agents in fawn-hooded rats.
11254584 - Different subsets of enteric bacteria induce and perpetuate experimental colitis in rat...
3244894 - A new method for collecting urine directly from the ureter in conscious unrestrained rats.
Publication Detail:
Type:  Journal Article; Review     Date:  2008-03-18
Journal Detail:
Title:  European journal of pharmacology     Volume:  585     ISSN:  0014-2999     ISO Abbreviation:  Eur. J. Pharmacol.     Publication Date:  2008 May 
Date Detail:
Created Date:  2008-04-25     Completed Date:  2008-07-18     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  1254354     Medline TA:  Eur J Pharmacol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  426-35     Citation Subset:  IM    
Affiliation:
Department of Psychopharmacology, Utrecht Institute of Pharmacological Sciences and Rudolf Magnus Institute of Neuroscience, Utrecht University, Utrecht, The Netherlands. address: j.s.w.chan@uu.nl
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Antidepressive Agents / adverse effects,  pharmacology
Ejaculation / drug effects
Female
Humans
Male
Serotonin / physiology
Serotonin Uptake Inhibitors / adverse effects,  pharmacology
Sexual Behavior, Animal / drug effects
Sexual Dysfunction, Physiological / chemically induced,  drug therapy*,  genetics*
Sexual Dysfunctions, Psychological / drug therapy*,  genetics*
Chemical
Reg. No./Substance:
0/Antidepressive Agents; 0/Serotonin Uptake Inhibitors; 50-67-9/Serotonin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Corticosteroid receptor-gene variants: modulators of the stress-response and implications for mental...
Next Document:  A life course of adiposity and dementia.