| Translational gastrointestinal pharmacology in the 21st century: 'the lesogaberan story' | |
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MedLine Citation:
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PMID: 22036168 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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The development of the novel γ-aminobutyric acid type-B receptor (GABA(B)) agonist lesogaberan is presented as an example of a partly successful translational strategy in the field of gastroenterology. Data on transient lower esophageal sphincter relaxations (TLESRs) and gastroesophageal reflux inhibition from preclinical models translated well to clinical studies in healthy volunteers and patients with gastroesophageal reflux disease (GERD). Animal models have also been used successfully to predict the effect of other target mechanisms on TLESRs in humans. However, while translation of physiology to symptomatology in patients with GERD was achieved, the effect size was too small to be of clinical significance. A deeper understanding of the cause of symptoms in different patient categories is therefore required. |
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Authors:
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Guy E Boeckxstaens; Hans Denison; Jörgen M Jensen; Anders Lehmann; Magnus Ruth |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-10-27 |
Journal Detail:
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Title: Current opinion in pharmacology Volume: - ISSN: 1471-4973 ISO Abbreviation: - Publication Date: 2011 Oct |
Date Detail:
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Created Date: 2011-10-31 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100966133 Medline TA: Curr Opin Pharmacol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2011 Elsevier Ltd. All rights reserved. |
Affiliation:
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Department of Gastroenterology, University Hospital Leuven, Catholic University of Leuven, Belgium. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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