| Translational control of mitochondrial energy production mediates neuron morphogenesis. | |
| | |
MedLine Citation:
|
PMID: 23217258 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
|
Mitochondrial energy production is a tightly regulated process involving the coordinated transcription of several genes, catalysis of a plethora of posttranslational modifications, and the formation of very large molecular supercomplexes. The regulation of mitochondrial activity is particularly important for the brain, which is a high-energy-consuming organ that depends on oxidative phosphorylation to generate ATP. Here we show that brain mitochondrial ATP production is controlled by the cytoplasmic polyadenylation-induced translation of an mRNA encoding NDUFV2, a key mitochondrial protein. Knockout mice lacking the Cytoplasmic Polyadenylation Element Binding protein 1 (CPEB1) have brain-specific dysfunctional mitochondria and reduced ATP levels, which is due to defective polyadenylation-induced translation of electron transport chain complex I protein NDUFV2 mRNA. This reduced ATP results in defective dendrite morphogenesis of hippocampal neurons both in vitro and in vivo. These and other results demonstrate that CPEB1 control of mitochondrial activity is essential for normal brain development. |
| | |
Authors:
|
Aparna Oruganty-Das; Teclise Ng; Tsuyoshi Udagawa; Eyleen L K Goh; Joel D Richter |
Related Documents
:
|
10364308 - Icp22 and the ul13 protein kinase are both required for herpes simplex virus-induced mo... 17251478 - Adenovirus type 37 keratitis in the c57bl/6j mouse. 8995628 - The adeno-associated virus (aav) rep protein acts as both a repressor and an activator ... 2173798 - Naf, a trans-regulating negative-acting factor encoded within the mouse mammary tumor v... 12030848 - Hormone-specific regulation of the kidney androgen-regulated gene promoter in cultured ... 7840908 - Consequences of prolonged inhalation of ozone on f344/n rats: collaborative studies. pa... |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Cell metabolism Volume: 16 ISSN: 1932-7420 ISO Abbreviation: Cell Metab. Publication Date: 2012 Dec |
Date Detail:
|
Created Date: 2012-12-10 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 101233170 Medline TA: Cell Metab Country: United States |
Other Details:
|
Languages: eng Pagination: 789-800 Citation Subset: IM |
Copyright Information:
|
Copyright © 2012 Elsevier Inc. All rights reserved. |
Affiliation:
|
Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Chronic Caloric Restriction Preserves Mitochondrial Function in Senescence without Increasing Mitoch...
Next Document: A heme-sensing mechanism in the translational regulation of mitochondrial cytochrome C oxidase bioge...