Document Detail


The translational landscape of the mammalian cell cycle.
MedLine Citation:
PMID:  24120665     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Gene regulation during cell-cycle progression is an intricately choreographed process, ensuring accurate DNA replication and division. However, the translational landscape of gene expression underlying cell-cycle progression remains largely unknown. Employing genome-wide ribosome profiling, we uncover widespread translational regulation of hundreds of mRNAs serving as an unexpected mechanism for gene regulation underlying cell-cycle progression. A striking example is the S phase translational regulation of RICTOR, which is associated with cell cycle-dependent activation of mammalian target of rapamycin complex 2 (mTORC2) signaling and accurate cell-cycle progression. We further identified unappreciated coordination in translational control of mRNAs within molecular complexes dedicated to cell-cycle progression, lipid metabolism, and genome integrity. This includes the majority of mRNAs comprising the cohesin and condensin complexes responsible for maintaining genome organization, which are coordinately translated during specific cell cycle phases via their 5' UTRs. Our findings illuminate the prevalence and dynamic nature of translational regulation underlying the mammalian cell cycle.
Authors:
Craig R Stumpf; Melissa V Moreno; Adam B Olshen; Barry S Taylor; Davide Ruggero
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2013-10-10
Journal Detail:
Title:  Molecular cell     Volume:  52     ISSN:  1097-4164     ISO Abbreviation:  Mol. Cell     Publication Date:  2013 Nov 
Date Detail:
Created Date:  2013-11-25     Completed Date:  2014-01-28     Revised Date:  2014-03-20    
Medline Journal Info:
Nlm Unique ID:  9802571     Medline TA:  Mol Cell     Country:  United States    
Other Details:
Languages:  eng     Pagination:  574-82     Citation Subset:  IM    
Copyright Information:
Copyright © 2013 Elsevier Inc. All rights reserved.
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MeSH Terms
Descriptor/Qualifier:
5' Untranslated Regions
Active Transport, Cell Nucleus / genetics
Adenosine Triphosphatases / genetics,  metabolism
Animals
Cell Cycle / genetics
Cell Cycle Proteins / genetics,  metabolism
Chromosomal Proteins, Non-Histone / genetics,  metabolism
Citric Acid Cycle / genetics
DNA Repair / genetics
DNA-Binding Proteins / genetics,  metabolism
Gene Expression Regulation*
Gene Regulatory Networks
Genome, Human
HeLa Cells
Humans
Lipid Metabolism / genetics
Mice
Mitosis / genetics*
Multiprotein Complexes / genetics,  metabolism
Protein Biosynthesis*
RNA, Messenger / genetics,  metabolism
Transcriptome
Grant Support
ID/Acronym/Agency:
F32CA162634/CA/NCI NIH HHS; P30CA82103/CA/NCI NIH HHS; R01 CA140456/CA/NCI NIH HHS; R01 CA154916/CA/NCI NIH HHS; R01CA140456/CA/NCI NIH HHS; R01CA154916/CA/NCI NIH HHS
Chemical
Reg. No./Substance:
0/5' Untranslated Regions; 0/Cell Cycle Proteins; 0/Chromosomal Proteins, Non-Histone; 0/DNA-Binding Proteins; 0/Multiprotein Complexes; 0/RNA, Messenger; 0/cohesins; 0/condensin complexes; EC 3.6.1.-/Adenosine Triphosphatases

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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