Document Detail

Translation deregulation in B-cell lymphomas.
MedLine Citation:
PMID:  21118132     Owner:  NLM     Status:  MEDLINE    
B-cell lymphomas are a heterogeneous group of diseases that can arise at different stages of B-cell development, often as a result of errors in the cells' unique ontogeny. Common oncogenic features are often observed, including chromosomal rearrangements, somatic mutations and transcriptional change. Disruption of translation regulation is also frequently implicated in both B-cell lymphoma development and progression. Deregulation of translation in lymphomagenesis can arise through changes to the proteins constituting the translational machinery or to their regulators, and to changes in miRNA (microRNA) expression.
Emilie Horvilleur; Lindsay A Wilson; Anne E Willis
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Biochemical Society transactions     Volume:  38     ISSN:  1470-8752     ISO Abbreviation:  Biochem. Soc. Trans.     Publication Date:  2010 Dec 
Date Detail:
Created Date:  2010-12-01     Completed Date:  2011-03-14     Revised Date:  2014-02-20    
Medline Journal Info:
Nlm Unique ID:  7506897     Medline TA:  Biochem Soc Trans     Country:  England    
Other Details:
Languages:  eng     Pagination:  1593-7     Citation Subset:  IM    
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MeSH Terms
B-Lymphocytes / pathology,  physiology
Gene Expression Regulation, Neoplastic
Lymphoma, B-Cell / classification,  diagnosis,  genetics*
MicroRNAs / genetics,  metabolism*
Protein Biosynthesis*
Grant Support
MC_UP_A600_1023//Medical Research Council; //Biotechnology and Biological Sciences Research Council; //Cancer Research UK
Reg. No./Substance:

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