Document Detail

Translation-Independent Localization of mRNA in E. coli.
MedLine Citation:
PMID:  21350180     Owner:  NLM     Status:  In-Data-Review    
Understanding the organization of a bacterial cell requires the elucidation of the mechanisms by which proteins localize to particular subcellular sites. Thus far, such mechanisms have been suggested to rely on embedded features of the localized proteins. Here, we report that certain messenger RNAs (mRNAs) in Escherichia coli are targeted to the future destination of their encoded proteins, cytoplasm, poles, or inner membrane in a translation-independent manner. Cis-acting sequences within the transmembrane-coding sequence of the membrane proteins are necessary and sufficient for mRNA targeting to the membrane. In contrast to the view that transcription and translation are coupled in bacteria, our results show that, subsequent to their synthesis, certain mRNAs are capable of migrating to particular domains in the cell where their future protein products are required.
Keren Nevo-Dinur; Anat Nussbaum-Shochat; Sigal Ben-Yehuda; Orna Amster-Choder
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Science (New York, N.Y.)     Volume:  331     ISSN:  1095-9203     ISO Abbreviation:  Science     Publication Date:  2011 Feb 
Date Detail:
Created Date:  2011-02-25     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0404511     Medline TA:  Science     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1081-4     Citation Subset:  IM    
Department of Microbiology and Molecular Genetics, Institute for Medical Research Israel-Canada, The Hebrew University Faculty of Medicine, Post Office Box 12272, Jerusalem 91120, Israel.
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Comment In:
Science. 2011 Feb 25;331(6020):1021-2   [PMID:  21350158 ]

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