Document Detail

Translating glycolytic metabolism to innate immunity in dendritic cells.
MedLine Citation:
PMID:  24807219     Owner:  NLM     Status:  In-Data-Review    
Growing evidence supports a role for glycolysis in immune activation. Everts et al. (2014) now show that TLR-mediated stimulation of dendritic cells rapidly induces glycolysis, which regenerates NADPH and TCA intermediates to support fatty acid production. This enhances ER and Golgi membrane synthesis and innate activation of dendritic cells.
Mario Cortese; Charles Sinclair; Bali Pulendran
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Cell metabolism     Volume:  19     ISSN:  1932-7420     ISO Abbreviation:  Cell Metab.     Publication Date:  2014 May 
Date Detail:
Created Date:  2014-05-08     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101233170     Medline TA:  Cell Metab     Country:  United States    
Other Details:
Languages:  eng     Pagination:  737-9     Citation Subset:  IM    
Copyright Information:
Copyright © 2014 Elsevier Inc. All rights reserved.
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