Document Detail

Translating cardioprotection for patient benefit: position paper from the Working Group of Cellular Biology of the Heart of the European Society of Cardiology.
MedLine Citation:
PMID:  23334258     Owner:  NLM     Status:  MEDLINE    
Coronary heart disease (CHD) is the leading cause of death and disability worldwide. Despite current therapy, the morbidity and mortality for patients with CHD remains significant. The most important manifestations of CHD arise from acute myocardial ischaemia-reperfusion injury (IRI) in terms of cardiomyocyte death and its long-term consequences. As such, new therapeutic interventions are required to protect the heart against the detrimental effects of acute IRI and improve clinical outcomes. Although a large number of cardioprotective therapies discovered in pre-clinical studies have been investigated in CHD patients, few have been translated into the clinical setting, and a significant number of these have failed to show any benefit in terms of reduced myocardial infarction and improved clinical outcomes. Because of this, there is currently no effective therapy for protecting the heart against the detrimental effects of acute IRI in patients with CHD. One major factor for this lack of success in translating cardioprotective therapies into the clinical setting can be attributed to problems with the clinical study design. Many of these clinical studies have not taken into consideration the important data provided from previously published pre-clinical and clinical studies. The overall aim of this ESC Working Group Cellular Biology of the Heart Position Paper is to provide recommendations for optimizing the design of clinical cardioprotection studies, which should hopefully result in new and effective therapeutic interventions for the future benefit of CHD patients.
Derek J Hausenloy; Hans Erik Bøtker; Gianluigi Condorelli; Peter Ferdinandy; David Garcia-Dorado; Gerd Heusch; Sandrine Lecour; Linda W van Laake; Rosalinda Madonna; Marisol Ruiz-Meana; Rainer Schulz; Joost P G Sluijter; Derek M Yellon; Michel Ovize
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2013-01-19
Journal Detail:
Title:  Cardiovascular research     Volume:  98     ISSN:  1755-3245     ISO Abbreviation:  Cardiovasc. Res.     Publication Date:  2013 Apr 
Date Detail:
Created Date:  2013-03-18     Completed Date:  2013-09-06     Revised Date:  2014-11-05    
Medline Journal Info:
Nlm Unique ID:  0077427     Medline TA:  Cardiovasc Res     Country:  England    
Other Details:
Languages:  eng     Pagination:  7-27     Citation Subset:  IM    
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MeSH Terms
Cardiopulmonary Bypass
Cardiopulmonary Resuscitation
Collateral Circulation
Coronary Artery Bypass
Coronary Circulation
Coronary Disease / complications,  therapy*
Disease Models, Animal
Heart Transplantation
Myocardial Reperfusion Injury / prevention & control*
Signal Transduction
Grant Support
FS/06/023//British Heart Foundation; MR/K002066/1//Medical Research Council; RG/08/015/26411//British Heart Foundation; //Department of Health

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