Document Detail


Translating induced pluripotent stem cells from bench to bedside: application to retinal diseases.
MedLine Citation:
PMID:  23320477     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Induced pluripotent stem cells (iPSc) are a scientific and medical frontier. Application of reprogrammed somatic cells for clinical trials is in its dawn period; advances in research with animal and human iPSc are paving the way for retinal therapies with the ongoing development of safe animal cell transplantation studies and characterization of patient- specific and disease-specific human iPSc. The retina is an optimal model for investigation of neural regeneration; amongst other advantageous attributes, it is the most accessible part of the CNS for surgery and outcome monitoring. A recent clinical trial showing a degree of visual restoration via a subretinal electronic prosthesis implies that even a severely degenerate retina may have the capacity for repair after cell replacement through potential plasticity of the visual system. Successful differentiation of neural retina from iPSc and the recent generation of an optic cup from human ESc invitro increase the feasibility of generating an expandable and clinically suitable source of cells for human clinical trials. In this review we shall present recent studies that have propelled the field forward and discuss challenges in utilizing iPS cell derived retinal cells as reliable models for clinical therapies and as a source for clinical cell transplantation treatment for patients suffering from genetic retinal disease.
Authors:
Alona O Cramer; Robert E MacLaren
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Current gene therapy     Volume:  13     ISSN:  1875-5631     ISO Abbreviation:  Curr Gene Ther     Publication Date:  2013 Apr 
Date Detail:
Created Date:  2013-03-27     Completed Date:  2013-09-23     Revised Date:  2013-12-04    
Medline Journal Info:
Nlm Unique ID:  101125446     Medline TA:  Curr Gene Ther     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  139-51     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Cell Differentiation
Clinical Trials as Topic
Humans
Induced Pluripotent Stem Cells / cytology,  transplantation*
Nuclear Reprogramming / genetics
Retina / pathology,  surgery,  transplantation
Retinal Degeneration / pathology,  therapy*
Retinal Diseases / pathology,  surgery,  therapy*
Translational Medical Research*
Grant Support
ID/Acronym/Agency:
//Medical Research Council; //Wellcome Trust
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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