Document Detail

Translatability of mRNA from brain of infant rabbits exposed chronically to aluminium.
MedLine Citation:
PMID:  2289617     Owner:  NLM     Status:  MEDLINE    
1. Polysomes were isolated from the brain of infant rabbits at 22 days of age. The animals received s.c. injections 3 times weekly of aluminium (Al) maltolate (3 mg Al/kg body wt) or Al lactate (16 mg Al/kg body wt) from 5 days of age. 2. The polysomes were used to direct the incorporation of [14C]leucine into peptides in a brain protein synthesizing system and exhibited a decreased activity when obtained from aluminum exposed infants. 3. The mRNA obtained from the polysomes was used to direct the incorporation of [35S]methionine into peptides in an mRNA dependent rabbit reticulocyte lysate. The translatability of the mRNA derived from aluminum exposed infant brains was significantly lower than that of preparations from control infant rabbits. 4. Al bound to maltolate, a ligand soluble in lipids as well as water, was considerably more detrimental to brain protein synthesis than Al bound to lactate.
D M Nicholls; G M Speares; S Asina; A C Miller
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The International journal of biochemistry     Volume:  22     ISSN:  0020-711X     ISO Abbreviation:  Int. J. Biochem.     Publication Date:  1990  
Date Detail:
Created Date:  1991-04-01     Completed Date:  1991-04-01     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0250365     Medline TA:  Int J Biochem     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  1119-25     Citation Subset:  IM    
Department of Biology, York University, Ontario, Canada.
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MeSH Terms
Aluminum / metabolism,  pharmacology,  toxicity*
Animals, Newborn / metabolism*
Brain / metabolism*,  ultrastructure
Lactates / pharmacology,  toxicity
Lactic Acid
Organometallic Compounds / pharmacology,  toxicity
Polyribosomes / metabolism
Protein Biosynthesis / drug effects*
Pyrones / pharmacology,  toxicity
RNA, Messenger / drug effects,  metabolism*
Reg. No./Substance:
0/Lactates; 0/Organometallic Compounds; 0/Pyrones; 0/RNA, Messenger; 23058-19-7/aluminum maltolate; 50-21-5/Lactic Acid; 7429-90-5/Aluminum

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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